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MedKoo Cat#: 525690 | Name: YL-0919
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

YL-0919 is a novel 5-HT1A receptor agonist and selective serotonin reuptake inhibitor.

Chemical Structure

YL-0919
YL-0919
CAS#1339058-04-6

Theoretical Analysis

MedKoo Cat#: 525690

Name: YL-0919

CAS#: 1339058-04-6

Chemical Formula: C18H23ClN2O2

Exact Mass: 0.0000

Molecular Weight: 334.84

Elemental Analysis: C, 64.57; H, 6.92; Cl, 10.59; N, 8.37; O, 9.56

Price and Availability

Size Price Availability Quantity
25mg USD 150.00 2 Weeks
50mg USD 250.00 2 Weeks
100mg USD 450.00 2 Weeks
200mg USD 750.00 2 Weeks
500mg USD 1,650.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
No Data
Synonym
YL-0919; YL 0919; YL0919
IUPAC/Chemical Name
1-(1-Benzyl-4-hydroxy-piperidin-4-ylmethyl)-1H-pyridin-2-one Hydrochloride
InChi Key
OXILSFMNCPZGAH-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H22N2O2.ClH/c21-17-8-4-5-11-20(17)15-18(22)9-12-19(13-10-18)14-16-6-2-1-3-7-16;/h1-8,11,22H,9-10,12-15H2;1H
SMILES Code
O=C1C=CC=CN1CC2(O)CCN(CC3=CC=CC=C3)CC2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 334.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang Y, Bai Y, Hou X, Yang Y, Ma H, Wang G, Li Y. Neuroprotective effects of hypidone hydrochloride (YL-0919) after traumatic brain injury in mice. Chin Med J (Engl). 2025 Jan 14. doi: 10.1097/CM9.0000000000003400. Epub ahead of print. PMID: 39809708. 2: Bai Y, Ma H, Zhang Y, Li J, Hou X, Yang Y, Wang G, Li Y. Hypidone hydrochloride (YL-0919) ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation. Neural Regen Res. 2025 Aug 1;20(8):2325-2336. doi: 10.4103/NRR.NRR-D-23-01424. Epub 2024 Apr 3. PMID: 39359091; PMCID: PMC11759037. 3: Li GX, Yan JZ, Sun SR, Hou XJ, Yin YY, Li YF. The role of 5-HTergic neuron activation in the rapid antidepressant-like effects of hypidone hydrochloride (YL-0919) in mice. Front Pharmacol. 2024 Sep 6;15:1428485. doi: 10.3389/fphar.2024.1428485. PMID: 39309007; PMCID: PMC11412804. 4: Wang JY, Ren P, Cui LY, Duan JY, Chen HL, Zeng ZR, Li YF. Astrocyte-specific activation of sigma-1 receptors in mPFC mediates the faster onset antidepressant effect by inhibiting NF-κB-induced neuroinflammation. Brain Behav Immun. 2024 Aug;120:256-274. doi: 10.1016/j.bbi.2024.06.008. Epub 2024 Jun 8. PMID: 38852761. 5: Chen HX, Jin ZL, Zhang LM, Xue R, Xu XD, Zhao N, Qiu ZK, Wang XW, Zhang YZ, Yang RF, Li YF. Retraction: Antidepressant-Like Activity of YL-0919: A Novel Combined Selective Serotonin Reuptake Inhibitor and 5-HT1A Receptor Agonist. PLoS One. 2024 May 24;19(5):e0304643. doi: 10.1371/journal.pone.0304643. PMID: 38787840; PMCID: PMC11125500. 6: Ren P, Wang JY, Chen HL, Wang Y, Cui LY, Duan JY, Guo WZ, Zhao YQ, Li YF. Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus. J Pharmacol Sci. 2024 Apr;154(4):236-245. doi: 10.1016/j.jphs.2024.02.003. Epub 2024 Feb 9. PMID: 38485341. 7: Gao Z, Xie S, Wang L, Jiang L, Zhou J, Liang M, Li G, Wang Z, Li Y, Li Y, Han G. Hypidone hydrochloride (YL-0919) protects mice from meningitis via Sigma1R-STAT1-NLRP3-GSDMD pathway. Int Immunopharmacol. 2024 Feb 15;128:111524. doi: 10.1016/j.intimp.2024.111524. Epub 2024 Jan 16. PMID: 38232537. 8: Yan JZ, Li GX, Sun SR, Cui LY, Yin YY, Li YF. A rate-limiting step in antidepressants onset: Excitation of glutamatergic pyramidal neurons in medial prefrontal cortex of rodents. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Mar 2;130:110911. doi: 10.1016/j.pnpbp.2023.110911. Epub 2023 Dec 6. PMID: 38065287. 9: Chang HX, Dai W, Bao JH, Li JF, Zhang JG, Li YF. Corrigendum: Essential role of microglia in the fast antidepressant action of ketamine and hypidone hydrochloride (YL-0919). Front Pharmacol. 2023 Jun 14;14:1232874. doi: 10.3389/fphar.2023.1232874. Erratum for: Front Pharmacol. 2023 May 26;14:1122541. doi: 10.3389/fphar.2023.1122541. PMID: 37388449; PMCID: PMC10304276. 10: Chang HX, Dai W, Bao JH, Li JF, Zhang JG, Li YF. Essential role of microglia in the fast antidepressant action of ketamine and hypidone hydrochloride (YL-0919). Front Pharmacol. 2023 May 26;14:1122541. doi: 10.3389/fphar.2023.1122541. Erratum in: Front Pharmacol. 2023 Jun 14;14:1232874. doi: 10.3389/fphar.2023.1232874. PMID: 37305539; PMCID: PMC10250639. 11: Li JF, Hu WY, Chang HX, Bao JH, Kong XX, Ma H, Li YF. Astrocytes underlie a faster-onset antidepressant effect of hypidone hydrochloride (YL-0919). Front Pharmacol. 2023 Mar 29;14:1175938. doi: 10.3389/fphar.2023.1175938. PMID: 37063256; PMCID: PMC10090319. 12: Ren P, Wang JY, Chen HL, Chang HX, Zeng ZR, Li GX, Ma H, Zhao YQ, Li YF. Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919). Eur J Pharmacol. 2023 May 5;946:175647. doi: 10.1016/j.ejphar.2023.175647. Epub 2023 Mar 8. PMID: 36898424. 13: Smith S, Sergio J, Coyle M, Elder K, Centner A, Cohen S, Terry M, Lipari N, Glinski J, Wheelis E, Budrow C, Bishop C. The effects of Vilazodone, YL-0919 and Vortioxetine in hemiparkinsonian rats. Psychopharmacology (Berl). 2022 Jul;239(7):2119-2132. doi: 10.1007/s00213-022-06078-9. Epub 2022 Mar 11. PMID: 35275226. 14: Zhang YM, Ye LY, Li TY, Guo F, Guo F, Li Y, Li YF. New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism. Acta Pharmacol Sin. 2022 Jul;43(7):1699-1709. doi: 10.1038/s41401-021-00807-0. Epub 2021 Nov 22. PMID: 34811511; PMCID: PMC9253340. 15: Liu WG, Zhang LM, Yao JQ, Yin YY, Zhang XY, Li YF, Cao JB. Anti-PTSD Effects of Hypidone Hydrochloride (YL-0919): A Novel Combined Selective 5-HT Reuptake Inhibitor/5-HT1A Receptor Partial Agonist/5-HT6 Receptor Full Agonist. Front Pharmacol. 2021 Feb 10;12:625547. doi: 10.3389/fphar.2021.625547. PMID: 33643051; PMCID: PMC7902863. 16: Yin YY, Tian CY, Fang XX, Shang C, Zhang LM, Xu Q, Li YF. The Faster-Onset Antidepressant Effects of Hypidone Hydrochloride (YL-0919) in Monkeys Subjected to Chronic Unpredictable Stress. Front Pharmacol. 2020 Nov 26;11:586879. doi: 10.3389/fphar.2020.586879. PMID: 33324217; PMCID: PMC7725870. 17: Li YF. A hypothesis of monoamine (5-HT) - Glutamate/GABA long neural circuit: Aiming for fast-onset antidepressant discovery. Pharmacol Ther. 2020 Apr;208:107494. doi: 10.1016/j.pharmthera.2020.107494. Epub 2020 Jan 25. PMID: 31991195. 18: Cui C, Wang H, Wang Z, Jiang J, Wu N, Cui B, Zhang Q, Zhao Q, Hu P. An ultra HPLC-MS/MS method for quantification of hypidone hydrochloride (YL-0919) and application to a pharmacokinetic study. Bioanalysis. 2019 Jun;11(13):1243-1254. doi: 10.4155/bio-2019-0111. Epub 2019 Aug 9. PMID: 31397579. 19: Sun LJ, Zhang LM, Liu D, Xue R, Liu YQ, Li L, Guo Y, Shang C, Yao JQ, Zhang YZ, Li YF. The faster-onset antidepressant effects of hypidone hydrochloride (YL-0919). Metab Brain Dis. 2019 Oct;34(5):1375-1384. doi: 10.1007/s11011-019-00439-8. Epub 2019 Jun 24. PMID: 31236807. 20: Ran Y, Jin Z, Chen X, Zhao N, Fang X, Zhang L, Zhang Y, Li Y. Hypidone Hydrochloride (YL-0919) Produces a Fast-Onset Reversal of the Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure. Front Cell Neurosci. 2018 Nov 20;12:395. doi: 10.3389/fncel.2018.00395. PMID: 30524234; PMCID: PMC6256289.

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