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MedKoo Cat#: 581139 | Name: DA 5018

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DA 5018 is a capsaicin derivative, it has the antipruritic effect. DA 5018 is also a new non-narcotic analgesic.

Chemical Structure

DA 5018
DA 5018
CAS#174661-97-3

Theoretical Analysis

MedKoo Cat#: 581139

Name: DA 5018

CAS#: 174661-97-3

Chemical Formula: C22H31ClN2O3

Exact Mass: 406.2023

Molecular Weight: 406.95

Elemental Analysis: C, 64.93; H, 7.68; Cl, 8.71; N, 6.88; O, 11.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
DA 5018; DA-5018; DA5018;UNII-51V6N8BA2P;
IUPAC/Chemical Name
2-(4-(2-aminoethoxy)-3-methoxyphenyl)-N-(3-(3,4-dimethylphenyl)propyl)acetamide hydrochloride
InChi Key
OUEKLNJUMVZULZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H30N2O3.ClH/c1-16-6-7-18(13-17(16)2)5-4-11-24-22(25)15-19-8-9-20(27-12-10-23)21(14-19)26-3;/h6-9,13-14H,4-5,10-12,15,23H2,1-3H3,(H,24,25);1H
SMILES Code
NCCOc1ccc(CC(NCCCc2ccc(C)c(C)c2)=O)cc1OC.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 406.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim DH, Ahn BO, Kim SH, Kim WB. Antipruritic effect of DA-5018, a capsaicin derivative, in mice. Arch Pharm Res. 1999 Dec;22(6):549-53. PubMed PMID: 10615858. 2: Kang YS, Kim JM. Permeability of a capsaicin derivative, [14C]DA-5018 to blood-brain barrier corrected with HPLC method. Arch Pharm Res. 1999 Apr;22(2):165-72. PubMed PMID: 10230507. 3: Lee JJ, Shim HJ, Kim SH, Lee SD, Kim WB, Yang J, Lee MG. Pharmacokinetics of a non-narcotic analgesic, DA-5018, in rats. Biopharm Drug Dispos. 1998 Mar;19(2):101-8. PubMed PMID: 9533110. 4: Shim HJ, Lee JJ, Lee SD, Kim WB, Yang J, Kim SH, Lee MG. Stability, blood partition, and protein binding of DA-5018, a new nonnarcotic analgesic. Res Commun Mol Pathol Pharmacol. 1996 Jan;91(1):97-108. PubMed PMID: 8824935. 5: Cha BJ, Lee ED, Kim WB, Chung SJ, Lee MH, Shim CK. Enhanced skin permeation of a new capsaicin derivative (DA-5018) from a binary vehicle system composed of isopropyl myristate and ethoxydiglycol. Arch Pharm Res. 2001 Jun;24(3):224-8. PubMed PMID: 11440082. 6: Shim HJ, Lee JJ, Lee SD, Kim WB, Yang J, Kim SH, Lee MG. Determination of a new non-narcotic analgesic, DA-5018, in plasma, urine and bile by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Feb 21;689(2):422-6. PubMed PMID: 9080332. 7: Park YH, You ES, Kim WB, Lee SS. DA-5018, a novel vanilloid type analgesic. Arch Pharm Res. 1997 Feb;20(1):93-5. PubMed PMID: 18975221. 8: Jung J, Hwang SW, Kwak J, Lee SY, Kang CJ, Kim WB, Kim D, Oh U. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J Neurosci. 1999 Jan 15;19(2):529-38. PubMed PMID: 9880573. 9: Shin JS, Wang MH, Hwang SW, Cho H, Cho SY, Kwon MJ, Lee SY, Oh U. Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists. Neurosci Lett. 2001 Feb 16;299(1-2):135-9. PubMed PMID: 11166956. 10: Pearce LV, Toth A, Ryu H, Kang DW, Choi HK, Jin MK, Lee J, Blumberg PM. Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2008 Apr;377(2):149-57. doi: 10.1007/s00210-007-0258-3. Epub 2008 Feb 8. PubMed PMID: 18259730; PubMed Central PMCID: PMC2931423. 11: Sim JH, Kim YC, Kim SJ, Lee SJ, Suh SH, Jun JY, So I, Kim KW. Capsaicin inhibits the voltage-operated calcium channels intracellularly in the antral circular myocytes of guinea-pig stomach. Life Sci. 2001 Apr 13;68(21):2347-60. PubMed PMID: 11350006.