TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels. It blocks the induced expression of inflammatory markers in microglial cells
MedKoo Cat#: 532817
Name: TG4-155
CAS#: 1164462-05-8
Chemical Formula: C23H26N2O4
Exact Mass: 394.1893
Molecular Weight: 394.47
Elemental Analysis: C, 70.03; H, 6.64; N, 7.10; O, 16.22
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 50.0 | 126.75 | |
| DMSO | 68.4 | 173.30 | |
| Ethanol | 6.0 | 15.11 |
The following data is based on the product molecular weight 394.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
