MedKoo Cat#: 556164 | Name: TGP-377421
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TGP-377421, also known as TGP-377/421 and Targapre-miR-377/421, is a potent miR-377 and miR-421 inhibitor that binds a functional site in both miRNAs.

Chemical Structure

TGP-377421
TGP-377421
CAS#16752-89-9

Theoretical Analysis

MedKoo Cat#: 556164

Name: TGP-377421

CAS#: 16752-89-9

Chemical Formula: C20H16N6

Exact Mass: 340.1436

Molecular Weight: 340.39

Elemental Analysis: C, 70.57; H, 4.74; N, 24.69

Price and Availability

Size Price Availability Quantity
100mg USD 1,650.00 2 Weeks
200mg USD 2,950.00 2 Weeks
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Related CAS #
No Data
Synonym
TGP-377421; TGP 377421; TGP377421; TGP-377/421; TGP 377/421; TGP377/421; Targapre-miR-377/421; Targapre-miR377/421; Targapre-miR 377/421;
IUPAC/Chemical Name
1H-Benzimidazol-5-amine, 2,2′-(1,3-phenylene)bis-
InChi Key
AQEJANNNADGRSY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H16N6/c21-13-4-6-15-17(9-13)25-19(23-15)11-2-1-3-12(8-11)20-24-16-7-5-14(22)10-18(16)26-20/h1-10H,21-22H2,(H,23,25)(H,24,26)
SMILES Code
NC1=CC=C2C(N=C(C3=CC=CC(C4=NC5=CC(N)=CC=C5N4)=C3)N2)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 340.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Haniff HS, Knerr L, Liu X, Crynen G, Boström J, Abegg D, Adibekian A, Lekah E, Wang KW, Cameron MD, Yildirim I, Lemurell M, Disney MD. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nat Chem. 2020 Oct;12(10):952-961. doi: 10.1038/s41557-020-0514-4. Epub 2020 Aug 24. PMID: 32839603; PMCID: PMC7571259.