TCS 2510 | CAS#346673-06-1| EP4 Agonist

MedKoo Cat#: 532814 | Name: TCS 2510

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCS 2510 is a highly selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM). TCS 2510 displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM.

Chemical Structure

TCS 2510

CAS#346673-06-1

Theoretical Analysis

MedKoo Cat#: 532814

Name: TCS 2510

CAS#: 346673-06-1

Chemical Formula: C21H29N5O2

Exact Mass: 383.2321

Molecular Weight: 383.50

Elemental Analysis: C, 65.77; H, 7.62; N, 18.26; O, 8.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TCS 2510, TCS-2510, TCS2510

IUPAC/Chemical Name

(5R)-5-[(E,3S)-3-hydroxy-4-phenylbut-1-enyl]-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one

InChi Key

JWYPJSNXPZTEHL-VJKINUSGSA-N

InChi Code

InChI=1S/C21H29N5O2/c27-19(16-17-8-4-3-5-9-17)13-11-18-12-14-21(28)26(18)15-7-2-1-6-10-20-22-24-25-23-20/h3-5,8-9,11,13,18-19,27H,1-2,6-7,10,12,14-16H2,(H,22,23,24,25)/b13-11+/t18-,19+/m0/s1

SMILES Code

O=C1N(CCCCCCC2=NNN=N2)[C@@H](/C=C/[C@@H](O)CC3=CC=CC=C3)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 383.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Stone AJ, Copp SW, Kaufman MP. Role of prostaglandins in spinal transmission of the exercise pressor reflex in decerebrated rats. Neuroscience. 2014 Sep 26;277:26-35. doi: 10.1016/j.neuroscience.2014.06.061. Epub 2014 Jul 5. PubMed PMID: 25003710; PubMed Central PMCID: PMC4164591. 2: Liu Y, Rajagopal M, Lee K, Battini L, Flores D, Gusella GL, Pao AC, Rohatgi R. Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1425-34. doi: 10.1152/ajprenal.00010.2012. Epub 2012 Aug 29. PubMed PMID: 22933297; PubMed Central PMCID: PMC3517629. 3: Han Y, Kang Y, Torres-Jerez I, Cheung F, Town CD, Zhao PX, Udvardi MK, Monteros MJ. Genome-wide SNP discovery in tetraploid alfalfa using 454 sequencing and high resolution melting analysis. BMC Genomics. 2011 Jul 6;12:1-11. doi: 10.1186/1471-2164-12-350. PubMed PMID: 21733171; PubMed Central PMCID: PMC3154875. 4: He X, Blount JW, Ge S, Tang Y, Dixon RA. A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata). Planta. 2011 Apr;233(4):843-55. doi: 10.1007/s00425-010-1344-1. Epub 2011 Jan 11. PubMed PMID: 21221632.