Dibenzoylmethane | CAS#120-46-7

MedKoo Cat#: 525321 | Name: Dibenzoylmethane

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dibenzoylmethane is a novel inhibitor of eIF2a-P activity, targeting eIF2a-P-mediated translational repression prevent neurodegeneration in mice.

Chemical Structure

Dibenzoylmethane

CAS#120-46-7

Theoretical Analysis

MedKoo Cat#: 525321

Name: Dibenzoylmethane

CAS#: 120-46-7

Chemical Formula: C15H12O2

Exact Mass: 224.0837

Molecular Weight: 224.26

Elemental Analysis: C, 80.34; H, 5.39; O, 14.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Dibenzoylmethane

IUPAC/Chemical Name

1,3-Diphenyl-propane-1,3-dione

InChi Key

NZZIMKJIVMHWJC-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-10H,11H2

SMILES Code

O=C(C1=CC=CC=C1)CC(C2=CC=CC=C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 224.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Siskos MG, Choudhary MI, Gerothanassis IP. Refinement of labile hydrogen positions based on DFT calculations of (1)H NMR chemical shifts: comparison with X-ray and neutron diffraction methods. Org Biomol Chem. 2017 May 17. doi: 10.1039/c7ob01019b. [Epub ahead of print] PubMed PMID: 28513720. 2: Knyazev AA, Karyakin ME, Krupin AS, Romanova KA, Galyametdinov YG. Influence of Eu(III) Complexes Structural Anisotropy on Luminescence of Doped Conjugated Polymer Blends. Inorg Chem. 2017 May 8. doi: 10.1021/acs.inorgchem.6b02825. [Epub ahead of print] PubMed PMID: 28481087. 3: Halliday M, Radford H, Zents KAM, Molloy C, Moreno JA, Verity NC, Smith E, Ortori CA, Barrett DA, Bushell M, Mallucci GR. Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice. Brain. 2017 Apr 19. doi: 10.1093/brain/awx074. [Epub ahead of print] PubMed PMID: 28430857. 4: Takano K, Ishida N, Kawabe K, Moriyama M, Hibino S, Choshi T, Hori O, Nakamura Y. A dibenzoylmethane derivative inhibits lipopolysaccharide-induced NO production in mouse microglial cell line BV-2. Neurochem Int. 2017 Apr 5. pii: S0197-0186(17)30133-X. doi: 10.1016/j.neuint.2017.04.002. [Epub ahead of print] PubMed PMID: 28390951. 5: Teimouri M, Junaid M, Saleem S, Khan A, Ali A. In-vitro analysis of selective nutraceuticals binding to human transcription factors through computer aided molecular docking predictions. Bioinformation. 2016 Oct 17;12(7):354-358. doi: 10.6026/97320630012354. eCollection 2016. PubMed PMID: 28246465; PubMed Central PMCID: PMC5311079. 6: Zhang K, Yuan C, Guo FS, Zhang YQ, Wang YY. Fine-tuning terminal solvent ligands to rationally enhance the energy barrier in dinuclear dysprosium single-molecule magnets. Dalton Trans. 2016 Dec 20;46(1):186-192. PubMed PMID: 27910974. 7: Almelah E, Smith DP, McGown A, Aziz A, Potgieter HJ, Ragazzon P. Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer. Anticancer Res. 2016 Nov;36(11):6043-6050. PubMed PMID: 27793931. 8: Kong X, Brinkmann A, Terskikh V, Wasylishen RE, Bernard GM, Duan Z, Wu Q, Wu G. Proton Probability Distribution in the O···H···O Low-Barrier Hydrogen Bond: A Combined Solid-State NMR and Quantum Chemical Computational Study of Dibenzoylmethane and Curcumin. J Phys Chem B. 2016 Nov 17;120(45):11692-11704. Epub 2016 Nov 8. PubMed PMID: 27782387. 9: Martincigh BS, Ollengo MA. The Photostabilizing Effect of Grape Seed Extract on Three Common Sunscreen Absorbers. Photochem Photobiol. 2016 Nov;92(6):870-884. doi: 10.1111/php.12652. Epub 2016 Nov 30. PubMed PMID: 27759892. 10: Zhou T, Jia L, Luo YF, Xu J, Chen RH, Ge ZJ, Ma TL, Chen H, Zhu TF. Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging. Int J Nanomedicine. 2016 Sep 19;11:4765-4776. eCollection 2016. PubMed PMID: 27698562; PubMed Central PMCID: PMC5034929. 11: Tikhonov SA, Vovna VI, Gelfand NA, Osmushko IS, Fedorenko EV, Mirochnik AG. Electronic Structure and Optical Properties of Boron Difluoride Dibenzoylmethane Derivatives. J Phys Chem A. 2016 Sep 22;120(37):7361-9. doi: 10.1021/acs.jpca.6b07242. Epub 2016 Sep 13. PubMed PMID: 27580170. 12: Pires GP, Costa IF, Brito HF, Faustino WM, Teotonio EE. Luminescent and magnetic materials with a high content of Eu(3+)-EDTA complexes. Dalton Trans. 2016 Jul 5;45(27):10960-8. doi: 10.1039/c6dt00249h. PubMed PMID: 27301580. 13: Retraction notice to “Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: Role of Michael acceptors and Michael donors” [Biochem. Pharmacol. 82 (2011) 1901–1909]. Biochem Pharmacol. 2016 Feb 15;102:144. doi: 10.1016/j.bcp.2015.11.009. Epub 2016 Feb 20. PubMed PMID: 26985466; PubMed Central PMCID: PMC4801119. 14: Ito F, Suzuki Y, Fujimori J, Sagawa T, Hara M, Seki T, Yasukuni R, Lamy de la Chapelle M. Direct Visualization of the Two-step Nucleation Model by Fluorescence Color Changes during Evaporative Crystallization from Solution. Sci Rep. 2016 Mar 8;6:22918. doi: 10.1038/srep22918. PubMed PMID: 26953165; PubMed Central PMCID: PMC4782171. 15: Zhang WY, Tian YM, Li HF, Chen P, Sun WB, Zhang YQ, Yan PF. A series of dinuclear Dy(iii) complexes bridged by 2-methyl-8-hydroxylquinoline: replacement on the periphery coordinated β-diketonate terminal leads to different single-molecule magnetic properties. Dalton Trans. 2016 Mar 7;45(9):3863-73. doi: 10.1039/c5dt04449a. Epub 2016 Feb 1. PubMed PMID: 26905041. 16: Li S, Lu G, Xie Z, Ding J, Liu J, Li Y. Sorption and degradation of selected organic UV filters (BM-DBM, 4-MBC, and OD-PABA) in laboratory water-sediment systems. Environ Sci Pollut Res Int. 2016 May;23(10):9679-89. doi: 10.1007/s11356-016-6126-2. Epub 2016 Feb 5. PubMed PMID: 26846244. 17: Armelao L, Belli Dell'Amico D, Bellucci L, Bottaro G, Labella L, Marchetti F, Samaritani S. Smart Grafting of Lanthanides onto Silica via N,N-Dialkylcarbamato Complexes. Inorg Chem. 2016 Jan 19;55(2):939-47. doi: 10.1021/acs.inorgchem.5b02535. Epub 2016 Jan 7. PubMed PMID: 26741027. 18: Wang Z, Yang H, He P, He Y, Zhao J, Tang H. A highly-efficient blue-light excitable red phosphor: intramolecular π-stacking interactions in one dinuclear europium(iii) complex. Dalton Trans. 2016 Feb 21;45(7):2839-44. doi: 10.1039/c5dt04407c. Epub 2015 Dec 17. PubMed PMID: 26673545. 19: Krishna GR, Devarapalli R, Prusty R, Liu T, Fraser CL, Ramamurty U, Reddy CM. Structure-mechanical property correlations in mechanochromic luminescent crystals of boron difluoride dibenzoylmethane derivatives. IUCrJ. 2015 Sep 22;2(Pt 6):611-9. doi: 10.1107/S2052252515015134. eCollection 2015 Nov 1. PubMed PMID: 26594368; PubMed Central PMCID: PMC4645105. 20: DeRosa CA, Kerr C, Fan Z, Kolpaczynska M, Mathew AS, Evans RE, Zhang G, Fraser CL. Tailoring Oxygen Sensitivity with Halide Substitution in Difluoroboron Dibenzoylmethane Polylactide Materials. ACS Appl Mater Interfaces. 2015 Oct 28;7(42):23633-43. doi: 10.1021/acsami.5b07126. Epub 2015 Oct 19. PubMed PMID: 26480236; PubMed Central PMCID: PMC4626297.