Synonym
PF-06807656; PF 06807656; PF06807656;
IUPAC/Chemical Name
3-(N-(4-chlorophenyl)sulfamoyl)-4-methoxy-N-(1-(2-methyl-2H-1,2,3-triazol-4-yl)ethyl)benzamide
InChi Key
DERVNKULTWJINM-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20ClN5O4S/c1-12(16-11-21-25(2)23-16)22-19(26)13-4-9-17(29-3)18(10-13)30(27,28)24-15-7-5-14(20)6-8-15/h4-12,24H,1-3H3,(H,22,26)
SMILES Code
O=C(NC(C1=NN(C)N=C1)C)C2=CC(S(=O)(NC3=CC=C(Cl)C=C3)=O)=C(OC)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
449.91
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors. Matthew F. Sammons*† , Sujay V. Kharade*‡, Kevin J. Filipski† , Markus Boehm† , Aaron C. Smith§, Andre Shavnya§, Dilinie P. Fernando§⊥, Matthew S. Dowling§, Philip A. Carpino† , Neil A. Castle∥#, Shannon G. Zellmer∥#, Brett M. Antonio∥#, James R. Gosset†, Anthony Carlo§, and Jerod S. Denton‡. † Pfizer Worldwide Research & Development, 610 Main Street, Cambridge, Massachusetts 02139, United States ‡ Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States § Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States Neusentis, Pfizer Worldwide Research & Development, Durham, North Carolina 27703, United States ACS Med. Chem. Lett., Article ASAP DOI: 10.1021/acsmedchemlett.7b00481 Publication Date (Web): January 19, 2018 Copyright © 2018 American Chemical Society
Verlee, A. (2019). Innovative synthetic methods toward potential anti-oxidative stress agents for plants (Doctoral dissertation, Ghent University).
