RS67506 HCl | CAS#168986-61-6 |160845-97-6 |5-HT4 Partial Agonist

MedKoo Cat#: 532592 | Name: RS67506 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RS67506 HCl is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.

Chemical Structure

RS67506 HCl

CAS#168986-61-6 (RS67506 HCl); 160845-97-6 (RS67506).

Theoretical Analysis

MedKoo Cat#: 532592

Name: RS67506 HCl

CAS#: 168986-61-6 (RS67506 HCl); 160845-97-6 (RS67506).

Chemical Formula: C18H29Cl2N3O4S

Exact Mass: 453.1256

Molecular Weight: 454.41

Elemental Analysis: C, 47.58; H, 6.43; Cl, 15.60; N, 9.25; O, 14.08; S, 7.06

Price and Availability

This product was removed for the commercial reasons.

Related CAS #

168986-61-6 (RS67506 HCl); 160845-97-6 (RS67506).

Synonym

RS67506 HCl; RS67506 HCl; RS67506; RS 67506; RS-67506.

IUPAC/Chemical Name

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride

InChi Key

GFWKWEHKHLTRRF-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H28ClN3O4S.ClH/c1-26-18-12-16(20)15(19)11-14(18)17(23)4-3-13-5-8-22(9-6-13)10-7-21-27(2,24)25;/h11-13,21H,3-10,20H2,1-2H3;1H

SMILES Code

CS(=O)(NCCN1CCC(CCC(C2=CC(Cl)=C(N)C=C2OC)=O)CC1)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 454.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nagakura Y, Ito H, Kiso T, Naitoh Y, Miyata K. The selective 5-hydroxytryptamine (5-HT)4-receptor agonist RS67506 enhances lower intestinal propulsion in mice. Jpn J Pharmacol. 1997 Jun;74(2):209-12. PubMed PMID: 9243330.