RP67580 |CAS#135911-02-3 |NK1 receptor antagonist

MedKoo Cat#: 532575 | Name: RP67580

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RP67580 is a potent and selective tachykinin NK1 receptor antagonist (Ki values are 2.9 nM and > 10 μM for rat NK1, and rat NK2 and NK3 receptors respectively). It displays higher affinity at rat and mouse than human receptors.

Chemical Structure

RP67580

CAS#135911-02-3

Theoretical Analysis

MedKoo Cat#: 532575

Name: RP67580

CAS#: 135911-02-3

Chemical Formula: C29H30N2O2

Exact Mass: 438.2307

Molecular Weight: 438.57

Elemental Analysis: C, 79.42; H, 6.90; N, 6.39; O, 7.30

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 450.00
50mg	USD 1,350.00

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Related CAS #

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Synonym

RP67580; RP 67580; RP-67580.

IUPAC/Chemical Name

(3aR,7aR)-2-[2-(2-methoxyphenyl)ethanimidoyl]-7,7-di(phenyl)-1,3,3a,5,6,7a-hexahydroisoindol-4-one

InChi Key

VWBOQFANCXZMAU-LOSJGSFVSA-N

InChi Code

InChI=1S/C29H30N2O2/c1-33-27-15-9-8-10-21(27)18-28(30)31-19-24-25(20-31)29(17-16-26(24)32,22-11-4-2-5-12-22)23-13-6-3-7-14-23/h2-15,24-25,30H,16-20H2,1H3/t24-,25+/m0/s1

SMILES Code

O=C1[C@@]2([H])CN(C(CC3=CC=CC=C3OC)=N)C[C@@]2([H])C(C4=CC=CC=C4)(C5=CC=CC=C5)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 438.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Substance P enhances the local activation of NK1R-expressing c-kit+ cardiac progenitor cells in right atrium of ischemia/reperfusion-injured heart. BMC Mol Cell Biol. 2020 Jun 9;21(1):41. doi: 10.1186/s12860-020-00286-x. PMID: 32517655; PMCID: PMC7285458. 5: Jeong YM, Cheng XW, Kim W. Substance P Administered after Myocardial Infarction Upregulates Microphthalmia-Associated Transcription Factor, GATA4, and the Expansion of c-Kit+ Cells. Stem Cells Int. 2020 Feb 10;2020:1835950. doi: 10.1155/2020/1835950. PMID: 32104183; PMCID: PMC7035579. 6: Zhong B, Ma S, Wang DH. Protease-activated receptor 2 protects against myocardial ischemia-reperfusion injury through the lipoxygenase pathway and TRPV1 channels. Exp Ther Med. 2019 Nov;18(5):3636-3642. doi: 10.3892/etm.2019.7987. Epub 2019 Sep 9. PMID: 31602241; PMCID: PMC6777326. 7: Zhong B, Ma S, Wang DH. TRPV1 Mediates Glucose-induced Insulin Secretion Through Releasing Neuropeptides. 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