BMS-929075 | CAS#1217338-97-0 | HCV NS5B inhibitor MedKoo

MedKoo Cat#: 530632 | Name: BMS-929075

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-929075 is a HCV NS5B Replicase Palm Site Allosteric Inhibitor. BMS-929075 exhibited a favorable cytotoxicity window. BMS-929075 demonstrated efficacy in a triple combination regimen in HCV replicon cells, and exhibited consistently high oral bioavailability and pharmacokinetic parameters across preclinical animal species. The human PK properties from the Phase I clinical studies of BMS-929075 were better than anticipated and suggested promising potential for QD administration.

Chemical Structure

BMS-929075

CAS#1217338-97-0

Theoretical Analysis

MedKoo Cat#: 530632

Name: BMS-929075

CAS#: 1217338-97-0

Chemical Formula: C31H24F2N4O3

Exact Mass: 538.1816

Molecular Weight: 538.55

Elemental Analysis: C, 69.14; H, 4.49; F, 7.06; N, 10.40; O, 8.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BMS-929075; BMS 929075; BMS929075.

IUPAC/Chemical Name

4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)benzofuran-3-carboxamide

InChi Key

LZAUGCMVNLZVJV-UHFFFAOYSA-N

InChi Code

InChI=1S/C31H24F2N4O3/c1-17-4-5-19(28(38)37-31(12-13-31)30-35-14-3-15-36-30)16-22(17)21-10-11-23-24(26(21)33)25(29(39)34-2)27(40-23)18-6-8-20(32)9-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,34,39)(H,37,38)

SMILES Code

O=C(C1=CC(C2=CC=C(OC(C3=CC=C(F)C=C3)=C4C(NC)=O)C4=C2F)=C(C)C=C1)NC5(CC5)C6=NC=CC=N6

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

The hepatitis C virus NS5B replicase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 538.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yeung KS, Beno BR, Parcella K, Bender JA, Grant-Young KA, Nickel A, Gunaga P, Anjanappa P, Bora RO, Selvakumar K, Rigat K, Wang YK, Liu M, Lemm JA, Mosure K, Sheriff S, Wan C, Witmer M, Kish K, Hanumegowda UM, Zhuo X, Shu YZ, Parker D, Haskell R, Ng A, Gao Q, Colston E, Raybon J, Grasela DM, Santone KS, Gao M, Meanwell NA, Sinz MW, Soars MG, Knipe JO, Roberts SB, Kadow JF. Discovery of an HCV NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J Med Chem. 2017 Apr 21. doi: 10.1021/acs.jmedchem.7b00328. [Epub ahead of print] PubMed PMID: 28430437.