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MedKoo Cat#: 591003 | Name: Dimetacrine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimetacrine (brand names Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.

Chemical Structure

Dimetacrine
CAS# 4757-55-5

Theoretical Analysis

MedKoo Cat#: 591003

Name: Dimetacrine

CAS#: 4757-55-5

Chemical Formula: C20H26N2

Exact Mass: 294.2096

Molecular Weight: 294.44

Elemental Analysis: C, 81.58; H, 8.90; N, 9.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dimetacrina; Dimetacrina [DCIT]; Dimetacrine
IUPAC/Chemical Name
9,9-Dimethyl-10-(3-(dimethylamino)propyl)acridan
InChi Key
RYQOGSFEJBUZBX-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H26N2/c1-20(2)16-10-5-7-12-18(16)22(15-9-14-21(3)4)19-13-8-6-11-17(19)20/h5-8,10-13H,9,14-15H2,1-4H3
SMILES Code
CN(CCCN1C2=CC=CC=C2C(C)(C)C3=C1C=CC=C3)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 294.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kameyama T, Nagasaka M, Yamada K. Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice. Neuropharmacology. 1985 Apr;24(4):285-90. PubMed PMID: 4039801. 2: Hertrich O. [Ataractic treatment in psychiatry and general medicine. Review of drugs. 5]. Fortschr Med. 1983 Jul 14;101(26):1250, 1252. German. PubMed PMID: 6884962. 3: Gasco MR, Carlotti ME. Kinetics and mechanism of oxidation of dimetacrine, imipramine and phenothiazine drugs. Pharm Acta Helv. 1979;54(1):26-31. PubMed PMID: 432247. 4: Neye J, Fenner H. [Pharmacokinetics of dimetacrine in rats (author's transl)]. Arch Pharm (Weinheim). 1979 Jan;312(1):2-12. German. PubMed PMID: 426616. 5: Neye J, Fenner H. [Biotransformation of dimetacrine in rats (author's transl)]. Arch Pharm (Weinheim). 1978 Dec;311(12):1042-50. German. PubMed PMID: 736760. 6: Ishitani R, Iwamoto T. Binding of H3-imipramine, H3-dimetacrine and S35-chlorpromazine to synaptosomes. Jpn J Pharmacol. 1978 Feb;28(1):85-92. PubMed PMID: 651018. 7: Ishitani R, Iwamoto T. Studies on the subsynaptosomal distribution of psychotropic drugs in rat cerebral cortex. Jpn J Pharmacol. 1977 Dec;27(6):755-62. PubMed PMID: 609148. 8: Gasco MR, Carlotti ME. Kinetics and mechanism of oxidation of dimetacrine, imipramine and phenothiazine drugs. Pharm Acta Helv. 1977;52(12):296-301. PubMed PMID: 615316. 9: Ishitani R, Iwamoto T. Distribution of H3-dimetacrine in rat cerebral cortex by electron microscopic autoradiography. Experientia. 1976 Oct 15;32(10):1306-8. PubMed PMID: 976450. 10: Biamino G, Schüren KP, Ramdohr B, Lohmann FW. [Effect of tricyclic antidepressive agents on hemodynamics and plasms norepinephrine level in man during rest and exertion]. Z Kardiol. 1976 Mar;65(4):319-27. German. PubMed PMID: 1266277. 11: Biamino G, Fenner H, Schüren KP, Neye J, Ramdohr B, Lohmann RW. Cardiovascular side effects of tricyclic antidepressants - a risk in the use of these drugs. Int J Clin Pharmacol Biopharm. 1975 Apr;11(3):253-61. PubMed PMID: 1150371. 12: Biamino G, Fenner H, Neye J, Schuren KP, Ramdohr B. Comparative in vitro and in vivo studies on the effects of tricyclic antidepressants on myocardial contractility. Recent Adv Stud Cardiac Struct Metab. 1975;10:59-69. PubMed PMID: 1209005. 13: Kato H, Noguchi Y, Takagi K. Comparison of cardiovascular toxicities induced by dimetacrine, imipramine and amitriptyline in isolated guinea pig atria and anesthetized dogs. Jpn J Pharmacol. 1974 Dec;24(6):885-91. PubMed PMID: 4463275. 14: Abuzzahab FS Sr. A double-blind investigation of dimethacrine versus imipramine in hospitalized depressive states. Int J Clin Pharmacol. 1973 Nov;8(3):244-53. PubMed PMID: 4149236. 15: Sausgruber H. [Status of clinical experiments with the thymoleptic-anxiolytic, dimethacrine]. Arzneimittelforschung. 1972 Aug;22(8):1390-9. German. PubMed PMID: 4564744. 16: Ishitani R, Sato T, Suga T, Kitagawa H. Studies on the ultrastructural distribution of H 3 -dimetacrine in rat cerebral cortex. Jpn J Pharmacol. 1972 Jun;22(3):313-23. PubMed PMID: 4539395. 17: Melo I. [Clinical trial of dimethacrine]. Rev Med Suisse Romande. 1971 Mar;91(3):183-94. French. PubMed PMID: 5092364. 18: Misurec J. EEC frequency analysis in the treatment with some antidepressive drugs (imipramine, amitriptyline, dibenzepine, dimethacrine). Act Nerv Super (Praha). 1971;13(3):218-9. PubMed PMID: 5113846. 19: Hrbek J, Komenda S, Siroká A, Macáková J. Acute effect of dimethacrine (50 mg), mefaxamide (200 mg), and dixyrazine (25 mg) on higher nervous activity in mn. Act Nerv Super (Praha). 1971;13(3):204-5. PubMed PMID: 5113842. 20: Ishitani R, Saito E, Kitagawa H. The pharmacological studies on dimetacrine. I. Studies on the absorption, distribution and excretion of H3-labeled dimetacrine in the rat. Jpn J Pharmacol. 1970 Sep;20(3):432-8. PubMed PMID: 5312397.