TC13172 | CAS#2093393-05-4 | Mixed Lineage Kinase Domain-Like Protein Inhibitor

MedKoo Cat#: 530631 | Name: TC13172

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC13172 is a mixed Lineage Kinase Domain-Like protein (MLKL) inhibitor with single nanomolar potency. TC13172 may provide powerful tools to study the biological function of MLKL and demonstrate that MLKL should be viewed as a druggable target.

Chemical Structure

TC13172

CAS#2093393-05-4

Theoretical Analysis

MedKoo Cat#: 530631

Name: TC13172

CAS#: 2093393-05-4

Chemical Formula: C17H18N4O5S

Exact Mass: 390.0998

Molecular Weight: 390.41

Elemental Analysis: C, 52.30; H, 4.65; N, 14.35; O, 20.49; S, 8.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

TC13172, TC 13172, TC-13172

IUPAC/Chemical Name

3-(3-(3-hydroxyphenyl)prop-2-yn-1-yl)-1,7-dimethyl-8-(methylsulfonyl)-3,4,5,7-tetrahydro-1H-purine-2,6-dione

InChi Key

MCGQDULPSMRNTM-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H18N4O5S/c1-19-13-14(18-16(19)27(3,25)26)21(17(24)20(2)15(13)23)9-5-7-11-6-4-8-12(22)10-11/h4,6,8,10,13-14,22H,9H2,1-3H3

SMILES Code

O=C1C2C(N=C(S(C)(=O)=O)N2C)N(CC#CC3=CC=CC(O)=C3)C(N1C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 390.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yan B, Liu L, Huang S, Ren Y, Wang H, Yao Z, Li L, Chen S, Wang X, Zhang Z. Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein. Chem Commun (Camb). 2017 Mar 28;53(26):3637-3640. doi: 10.1039/c7cc00667e. PubMed PMID: 28267172.