SAR-20347 is a potent dual inhibitor of JAK1 and tyrosine kinase 2 (TYK2). SAR-20347 dose dependently (1 nM-10 μM) inhibited JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-α receptors. In vivo, TYK2 mutant mice or treatment of wild-type mice with SAR-20347 significantly reduced IL-12-induced IFN-γ production and IL-22-dependent serum amyloid A to similar extents.
MedKoo Cat#: 407471
Name: SAR-20347
CAS#: 1450881-55-6
Chemical Formula: C21H18ClFN4O4
Exact Mass: 444.1001
Molecular Weight: 444.85
Elemental Analysis: C, 56.70; H, 4.08; Cl, 7.97; F, 4.27; N, 12.59; O, 14.39
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 94.5 | 212.43 |
The following data is based on the product molecular weight 444.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
