BCM-599 is a HBV capsid assembly inhibitor. BCM-599 could be utilized as an effective combination treatment against HBV infection. BCM-599 showed IC50 of 0.88 μM and CC50 of 144 μM in HepG2.2.15 cells. BCM-599 decreased both intracellular and extracellular viral DNA levels without affecting the pgRNA level; moreover, interestingly, at the concentration of 0.88 μM, BCM-599 reduced the intracellular capsid level by 51% while increased the amount of free core protein dimer by 5-fold.
MedKoo Cat#: 530618
Name: BCM-599
CAS#: 1820763-99-2
Chemical Formula: C14H10Cl2FN3O2
Exact Mass: 341.0134
Molecular Weight: 342.15
Elemental Analysis: C, 49.15; H, 2.95; Cl, 20.72; F, 5.55; N, 12.28; O, 9.35
The following data is based on the product molecular weight 342.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
