BCN-PEG3-VC-PFP Ester is a cleavable ADC linker. PFP ester can be reactive with amine-bearing molecule to form stable amide bond. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The BCN group can react with azide-tagged biomolecules.
MedKoo Cat#: 235340
Name: BCN-PEG3-VC-PFP Ester
CAS#: 2353409-45-5
Chemical Formula: C37H50F5N5O10
Exact Mass: 819.3478
Molecular Weight: 819.82
Elemental Analysis: C, 54.21; H, 6.15; F, 11.59; N, 8.54; O, 19.52
The following data is based on the product molecular weight 819.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
