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MedKoo Cat#: 530615 | Name: SLC5111312 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLC5111312 is a SphK1/SphK2 dual-inhibitor.

Chemical Structure

SLC5111312 HCl
SLC5111312 HCl
CAS#1870811-01-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 530615

Name: SLC5111312 HCl

CAS#: 1870811-01-0 (HCl)

Chemical Formula: C22H28ClN5O3

Exact Mass:

Molecular Weight: 445.95

Elemental Analysis: C, 59.25; H, 6.33; Cl, 7.95; N, 15.70; O, 10.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
1870811-00-9 (free base) 1870811-01-0 (HCl)
Synonym
SLC5111312; SLC-5111312; SLC 5111312; SLC5111312 HCl; SLC5111312 hydrochloride
IUPAC/Chemical Name
(2S,3S)-3-hydroxy-2-(3-(6-(pentyloxy)naphthalen-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride
InChi Key
SYUYODDXPKNMOE-HLRBRJAUSA-N
InChi Code
InChI=1S/C22H27N5O3.ClH/c1-2-3-4-11-29-17-8-7-14-12-16(6-5-15(14)13-17)20-25-21(30-26-20)19-18(28)9-10-27(19)22(23)24;/h5-8,12-13,18-19,28H,2-4,9-11H2,1H3,(H3,23,24);1H/t18-,19-;/m0./s1
SMILES Code
NC(N1CC[C@@H]([C@H]1C2=NC(C3=CC4=CC=C(C=C4C=C3)OCCCCC)=NO2)O)=N.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues. This S1P concentration difference is necessary for proper lymphocyte egress from secondary lymphoid tissue and to maintain endothelial barrier integrity.

Preparing Stock Solutions

The following data is based on the product molecular weight 445.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kharel Y, Morris EA, Congdon MD, Thorpe SB, Tomsig JL, Santos WL, Lynch KR. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31. doi: 10.1124/jpet.115.225862. Epub 2015 Aug 4. PubMed PMID: 26243740; PubMed Central PMCID: PMC4576667.