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MedKoo Cat#: 532546 | Name: Ro01-6128
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro01-6128 is a positive allosteric modulator of mGlu1 receptors. Ro01-6128 potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a).

Chemical Structure

Ro01-6128
Ro01-6128
CAS#302841-86-7

Theoretical Analysis

MedKoo Cat#: 532546

Name: Ro01-6128

CAS#: 302841-86-7

Chemical Formula: C17H17NO3

Exact Mass: 283.1208

Molecular Weight: 283.33

Elemental Analysis: C, 72.07; H, 6.05; N, 4.94; O, 16.94

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Ro01-6128; Ro-01-6128; Ro 01-6128.
IUPAC/Chemical Name
ethyl N-[2,2-di(phenyl)acetyl]carbamate
InChi Key
ILSZPWZFQHSKLW-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H17NO3/c1-2-21-17(20)18-16(19)15(13-9-5-3-6-10-13)14-11-7-4-8-12-14/h3-12,15H,2H2,1H3,(H,18,19,20)
SMILES Code
O=C(OCC)NC(C(C1=CC=CC=C1)C2=CC=CC=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 283.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Brock et al (2007) Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J.Biol.Chem. 282 33000. PMID: 17855348. 2. Hemstapat et al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616. PMID: 16645124. 3: Pin, J. P., Goudet, C., Kniazeff, J., Hlavackova, V., Brock, C., Binet, V., ... & Prezeau, L. (2006). Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors?. In Insights into Receptor Function and New Drug Development Targets (pp. 105-115). Berlin, Heidelberg: Springer Berlin Heidelberg. 4: Goudet, C., Kniazeff, J., Hlavackova, V., Malhaire, F., Maurel, D., Acher, F., ... & Pin, J. P. (2005). Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. Journal of Biological Chemistry, 280(26), 24380-24385. 5: Trinquet, E., Fink, M., Bazin, H., Grillet, F., Maurin, F., Bourrier, E., ... & Mathis, G. (2006). D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1, 4, 5-tris phosphate to monitor G protein-coupled receptor activation. Analytical biochemistry, 358(1), 126-135.