R214127 | CAS#409345-76-2

MedKoo Cat#: 532488 | Name: R214127

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R214127 is a novel high-affinity radioligand for the mGlu1 receptor.

Chemical Structure

R214127

CAS#409345-76-2

Theoretical Analysis

MedKoo Cat#: 532488

Name: R214127

CAS#: 409345-76-2

Chemical Formula: C20H17NO2

Exact Mass: 303.1259

Molecular Weight: 303.36

Elemental Analysis: C, 79.19; H, 5.65; N, 4.62; O, 10.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

R214127; R 214127; R-214127.

IUPAC/Chemical Name

1-(3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-2-phenylethanone

InChi Key

HXUSRWUBSYSWII-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H17NO2/c22-19(11-14-5-2-1-3-6-14)15-8-9-18-17(12-15)13-16-7-4-10-23-20(16)21-18/h1-3,5-6,8-9,12-13H,4,7,10-11H2

SMILES Code

O=C(C1=CC=C2N=C3C(CCCO3)=CC2=C1)CC4=CC=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 303.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Simon L, Toth J, Molnar L, Agoston DV. MRI analysis of mGluR5 and mGluR1 antagonists, MTEP and R214127 in the cerebral forebrain of awake, conscious rats. Neurosci Lett. 2011 Nov 14;505(2):155-9. doi: 10.1016/j.neulet.2011.10.010. Epub 2011 Oct 12. PubMed PMID: 22015763. 2: Lavreysen H, Pereira SN, Leysen JE, Langlois X, Lesage AS. Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: a quantitative autoradiographic study using [3H]R214127. Neuropharmacology. 2004 Apr;46(5):609-19. PubMed PMID: 14996538. 3: Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. PubMed PMID: 12695537.