PSB-0963 is a small-molecule inhibitor targeting ecto-5'-nucleotidase (CD73), an enzyme implicated in the immunosuppressive tumor microenvironment. In vitro studies have demonstrated that PSB-0963 exhibits inhibitory activity against soluble rat CD73, with a pKi value of 6.8, corresponding to a Ki of 150 nM. Additionally, PSB-0963 has been reported to inhibit human ectonucleoside triphosphate diphosphohydrolase 1 (CD39), another enzyme involved in purinergic signaling, with a pKi value of 5.6, equating to a Ki of approximately 2.59 µM. These findings suggest that PSB-0963 may serve as a valuable tool for modulating purinergic signaling pathways in cancer research and immunotherapy development.
MedKoo Cat#: 532479
Name: PSB-0963 sodium
CAS#: 1213268-73-5 (sodium)
Chemical Formula: C28H17N2NaO5S
Exact Mass: 0.0000
Molecular Weight: 516.50
Elemental Analysis: C, 65.11; H, 3.32; N, 5.42; Na, 4.45; O, 15.49; S, 6.21
The following data is based on the product molecular weight 516.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |