MedKoo Cat#: 540004 | Name: L-Alaninol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Alaninol , also known as 2-Aminopropanol, is an amino acid derivative that inhibits melanoma proliferation and increases cytrochrome C reductase and tau-glutamyl transpeptidase.

Chemical Structure

L-Alaninol
L-Alaninol
CAS#2749-11-3

Theoretical Analysis

MedKoo Cat#: 540004

Name: L-Alaninol

CAS#: 2749-11-3

Chemical Formula: C3H9NO

Exact Mass: 75.0684

Molecular Weight: 75.11

Elemental Analysis: C, 47.97; H, 12.08; N, 18.65; O, 21.30

Price and Availability

Size Price Availability Quantity
5mL USD 250.00 2 Weeks
25mL USD 550.00 2 Weeks
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Related CAS #
No Data
Synonym
2-Aminopropanol; L-Alaninol
IUPAC/Chemical Name
2-aminopropan-1-ol
InChi Key
BKMMTJMQCTUHRP-UHFFFAOYSA-N
InChi Code
InChI=1S/C3H9NO/c1-3(4)2-5/h3,5H,2,4H2,1H3
SMILES Code
CC(N)CO
Appearance
Light yellow oil
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
L-Alaninol , also known as 2-Aminopropanol, is an amino acid derivative that inhibits melanoma proliferation and increases cytrochrome C reductase and tau-glutamyl transpeptidase.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 75.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Sivaramakrishna D, Swamy MJ. Synthesis, characterization and thermotropic phase behavior of a homologous series of N-acyl-L-alaninols and interaction of N-myristoyl L-alaninol with dimyristoylphosphatidylcholine. Chem Phys Lipids. 2016 Mar;196:5-12. doi: 10.1016/j.chemphyslip.2016.01.001. Epub 2016 Jan 29. PubMed PMID: 26827903. 2: de Azevedo Wäsch SI, van der Ploeg JR, Maire T, Lebreton A, Kiener A, Leisinger T. Transformation of isopropylamine to L-alaninol by Pseudomonas sp. strain KIE171 involves N-glutamylated intermediates. Appl Environ Microbiol. 2002 May;68(5):2368-75. PubMed PMID: 11976110; PubMed Central PMCID: PMC127573. 3: Hsu FF, Pacheco S, Turk J, Purdy G. Structural determination of glycopeptidolipids of Mycobacterium smegmatis by high-resolution multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Mass Spectrom. 2012 Oct;47(10):1269-81. doi: 10.1002/jms.3070. PubMed PMID: 23019158; PubMed Central PMCID: PMC3462375. 4: Kabeshov MA, Kysilka O, Rulíšek L, Suleimanov YV, Bella M, Malkov AV, Kočovský P. Cross-Aldol Reaction of Isatin with Acetone Catalyzed by Leucinol: A Mechanistic Investigation. Chemistry. 2015 Aug 17;21(34):12026-33. doi: 10.1002/chem.201500536. Epub 2015 Jul 6. PubMed PMID: 26147182. 5: York MJ, Crossley MJ, Hyslop SJ, Fisher ML, Kuchel PW. gamma-Glutamylcyclotransferase: inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect. Eur J Biochem. 1989 Sep 1;184(1):97-101. PubMed PMID: 2570694. 6: Bruneteau M, Michel G. Synthese du L-alaninol a partir d'extraits acellulaires de Mycobacterium avium. FEBS Lett. 1971 Apr 12;14(1):57-60. French. PubMed PMID: 11945718. 7: Ichimura N, Kasama T. Identification of valine- or leucine-containing glycopeptidolipids from Mycobacterium avium-intracellulare complex. Curr Microbiol. 2012 Jun;64(6):561-8. doi: 10.1007/s00284-012-0107-6. Epub 2012 Mar 22. PubMed PMID: 22437852. 8: Matsunaga I, Komori T, Mori N, Sugita M. Identification of a novel tetrapeptide structure of the Mycobacterium avium glycopeptidolipid that functions as a specific target for the host antibody response. Biochem Biophys Res Commun. 2012 Mar 23;419(4):687-91. doi: 10.1016/j.bbrc.2012.02.079. Epub 2012 Feb 20. PubMed PMID: 22382026. 9: Belisle JT, McNeil MR, Chatterjee D, Inamine JM, Brennan PJ. Expression of the core lipopeptide of the glycopeptidolipid surface antigens in rough mutants of Mycobacterium avium. J Biol Chem. 1993 May 15;268(14):10510-6. PubMed PMID: 8486703. 10: Jere FT, Miller DJ, Jackson JE. Stereoretentive C-H bond activation in the aqueous phase catalytic hydrogenation of amino acids to amino alcohols. Org Lett. 2003 Feb 20;5(4):527-30. PubMed PMID: 12583760. 11: Landau O, Wasserman L, Deutsch AA, Reiss R, Panet H, Novogrodsky A, Nordenberg J. Amino acid alcohols: growth inhibition and induction of differentiated features in melanoma cells. Cancer Lett. 1993 May 14;69(3):203-8. PubMed PMID: 8099846. 12: Cheong WY, Huang Y, Dangaria N, Gellman AJ. Probing enantioselectivity on chirally modified Cu(110), Cu(100), and Cu(111) surfaces. Langmuir. 2010 Nov 2;26(21):16412-23. doi: 10.1021/la102074a. PubMed PMID: 20973584. 13: Mukherjee R, Gomez M, Jayaraman N, Smith I, Chatterji D. Hyperglycosylation of glycopeptidolipid of Mycobacterium smegmatis under nutrient starvation: structural studies. Microbiology. 2005 Jul;151(Pt 7):2385-92. PubMed PMID: 16000728. 14: Nishikawa K. [Structure and antigenicity of the glycopeptidolipid antigen of Mycobacterium avium-intracellulare complex (MAC) serovar 16]. Kekkaku. 1998 Apr;73(4):295-306. Japanese. PubMed PMID: 9613050. 15: Pfuetzner RA, Chan WW. Synergistic binding of hydrophobic probes and zinc ligands to thermolysin. Eur J Biochem. 1993 Dec 1;218(2):523-8. PubMed PMID: 8269942. 16: Grubmeyer CT, Insinga S, Bhatia M, Moazami N. Salmonella typhimurium histidinol dehydrogenase: complete reaction stereochemistry and active site mapping. Biochemistry. 1989 Oct 3;28(20):8174-80. PubMed PMID: 2690936.