APY29, also known as ASC-29, is a IRE1α inhibitor. The accumulation of unfolded proteins under endoplasmic reticulum (ER) stress leads to the activation of the multidomain protein sensor IRE1α as part of the unfolded protein response (UPR). ATP-competitive inhibitors of IRE1α promote dimerization and activation of RNase activity despite blocking kinase autophosphorylation.
MedKoo Cat#: 530398
Name: APY29
CAS#: 1216665-49-4
Chemical Formula: C17H16N8
Exact Mass: 332.1498
Molecular Weight: 332.37
Elemental Analysis: C, 61.43; H, 4.85; N, 33.71
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| Ethanol:PBS (pH 7.2) (1:3) | 0.3 | 0.75 | ||
| Ethanol | 15.0 | 45.13 |
The following data is based on the product molecular weight 332.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
