NVP ACQ090 | CAS# 362612-47-3 | SST(3) Receptor Antagonist

MedKoo Cat#: 532376 | Name: NVP ACQ090

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NVP ACQ090 is a novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonist.

Chemical Structure

NVP ACQ090

CAS#362612-47-3 (free base)

Theoretical Analysis

MedKoo Cat#: 532376

Name: NVP ACQ090

CAS#: 362612-47-3 (free base)

Chemical Formula: C30H40F2N4O2

Exact Mass: 526.3119

Molecular Weight: 526.67

Elemental Analysis: C, 68.42; H, 7.66; F, 7.21; N, 10.64; O, 6.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

649761-71-7 (tartrate) 362612-47-3 (free base) 1221509-66-5 (fumarate)

Synonym

NVP ACQ090; NVPACQ090; NVP-ACQ090; ACQ090; ACQ-090; ACQ 090;

IUPAC/Chemical Name

[(4S,4aS,8aR)-2-[3-(6-methoxypyridin-3-yl)-2-methylpropyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-4-yl]-[4-(3,4-difluorophenyl)piperazin-1-yl]methanone

InChi Key

RDSAUPRYZCQORM-RIVQXRJNSA-N

InChi Code

InChI=1S/C30H40F2N4O2/c1-21(15-22-7-10-29(38-2)33-17-22)18-34-19-23-5-3-4-6-25(23)26(20-34)30(37)36-13-11-35(12-14-36)24-8-9-27(31)28(32)16-24/h7-10,16-17,21,23,25-26H,3-6,11-15,18-20H2,1-2H3/t21?,23-,25-,26+/m0/s1

SMILES Code

O=C([C@@H]1CN(CC(C)CC2=CC=C(OC)N=C2)C[C@]3([H])CCCC[C@]13[H])N4CCN(C5=CC=C(F)C(F)=C5)CC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 526.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lehmann A, Kliewer A, Günther T, Nagel F, Schulz S. Identification of Phosphorylation Sites Regulating sst3 Somatostatin Receptor Trafficking. Mol Endocrinol. 2016 Jun;30(6):645-59. doi: 10.1210/me.2015-1244. Epub 2016 Apr 21. PubMed PMID: 27101376. 2: Einstein EB, Patterson CA, Hon BJ, Regan KA, Reddi J, Melnikoff DE, Mateer MJ, Schulz S, Johnson BN, Tallent MK. Somatostatin signaling in neuronal cilia is critical for object recognition memory. J Neurosci. 2010 Mar 24;30(12):4306-14. doi: 10.1523/JNEUROSCI.5295-09.2010. PubMed PMID: 20335466; PubMed Central PMCID: PMC3842454. 3: Troxler T, Hurth K, Schuh KH, Schoeffter P, Langenegger D, Enz A, Hoyer D. Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1728-34. doi: 10.1016/j.bmcl.2010.01.063. Epub 2010 Jan 21. PubMed PMID: 20137944.