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MedKoo Cat#: 528525 | Name: CERM11956 fumarate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CERM-11956 is a calcium channel antagonist potentially for the treatment of myocardia ischemia. CERM-11956 led to slightly increased ATP levels in ischaemic hearts as compared to the control value in ischaemic hearts.

Chemical Structure

CERM11956 fumarate
CAS#97631-49-7 (fumarate)

Theoretical Analysis

MedKoo Cat#: 528525

Name: CERM11956 fumarate

CAS#: 97631-49-7 (fumarate)

Chemical Formula: C29H38N2O7

Exact Mass:

Molecular Weight: 526.63

Elemental Analysis: C, 66.14; H, 7.27; N, 5.32; O, 21.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
97631-49-7 (fumarate) 97631-46-4 (free base)
Synonym
CERM-11956; CERM 11956; CERM11956
IUPAC/Chemical Name
N-benzyl-N-(3-isobutoxy-2-(pyrrolidin-1-yl)propyl)benzo[d][1,3]dioxol-5-amine fumarate
InChi Key
AZZVBCJRSYUICI-WLHGVMLRSA-N
InChi Code
InChI=1S/C25H34N2O3.C4H4O4/c1-20(2)17-28-18-23(26-12-6-7-13-26)16-27(15-21-8-4-3-5-9-21)22-10-11-24-25(14-22)30-19-29-24;5-3(6)1-2-4(7)8/h3-5,8-11,14,20,23H,6-7,12-13,15-19H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES Code
CC(C)COCC(N1CCCC1)CN(C2=CC=C(OCO3)C3=C2)CC4=CC=CC=C4.O=C(O)/C=C/C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 526.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hugtenburg JG, Mathy MJ, de Haan N, Beckeringh JJ, van Zwieten PA. The influence of calcium antagonists on the adenine nucleotide metabolism in the guinea-pig working heart during ischaemia and reperfusion. Naunyn Schmiedebergs Arch Pharmacol. 1991 May;343(5):496-504. PubMed PMID: 1881460. 2: Hugtenburg JG, Mathy MJ, Veldsema-Currie RD, Boddeke HW, Beckeringh JJ, van Zwieten PA. A comparison of the cardioprotective effects of calcium antagonists from different classes upon ischaemic damage in the guinea-pig working heart. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):126-34. PubMed PMID: 2797212. 3: Boddeke EW, Wilffert B, Heynis JB, Hugtenburg JG, Jap WT, Veldsema-Currie RD, Van Zwieten PA. The anti-ischaemic activity of the novel compound, CERM 11956, compared with that of bepridil and nifedipine in isolated guinea-pig hearts. Eur J Pharmacol. 1988 May 10;149(3):195-203. PubMed PMID: 3261692.