GSK2263167 | 1165924-28-6 | 1165923-54-5 | 1458576-13-0 | SIP1 agopnist

MedKoo Cat#: 530564 | Name: GSK2263167

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK2263167 is a S1P1 receptor agonist.

Chemical Structure

GSK2263167

CAS#1165924-28-6 (free acid)

Theoretical Analysis

MedKoo Cat#: 530564

Name: GSK2263167

CAS#: 1165924-28-6 (free acid)

Chemical Formula: C25H26N4O4

Exact Mass: 446.1954

Molecular Weight: 446.51

Elemental Analysis: C, 67.25; H, 5.87; N, 12.55; O, 14.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1165924-28-6 (free acid) 1165923-54-5 (sodium) 1458576-13-0 (hydrate)

Synonym

GSK2263167; GSK-2263167; GSK 2263167.

IUPAC/Chemical Name

3-[6-(5-{3-Cyano-4-[(1 -methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-5-methyl- 3,4-dihydro-2(1H)-isoquinolinyl]propanoic acid

InChi Key

KYDLFNMKNFOMEK-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H26N4O4/c1-15(2)32-22-7-5-17(12-19(22)13-26)25-27-24(28-33-25)21-6-4-18-14-29(11-9-23(30)31)10-8-20(18)16(21)3/h4-7,12,15H,8-11,14H2,1-3H3,(H,30,31)

SMILES Code

O=C(O)CCN1CC2=C(C(C)=C(C3=NOC(C4=CC=C(OC(C)C)C(C#N)=C4)=N3)C=C2)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Agonists of the S1 P1 receptor have been used in a number of autoimmune and transplantation animal models, including Experimental Autoimmune Encephalomelitis (EAE) models of MS, to reduce the severity of the induced disease

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 446.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Robert M. Harris *, Benjamin I. Andrews , Stacy Clark , Jason W. B. Cooke , John C. S. Gray , andStephanie Q. Q. Ng Chemical Development, GlaxoSmithKline Research and Development Ltd., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K. Org. Process Res. Dev., 2013, 17 (10), pp 1239–1246 DOI: 10.1021/op400162p