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MedKoo Cat#: 528826 | Name: Nicousamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nicousamide is a TGF-β inhibitor potentially for the treatment of renal insufficiency.

Chemical Structure

Nicousamide
CAS#704881-43-6

Theoretical Analysis

MedKoo Cat#: 528826

Name: Nicousamide

CAS#: 704881-43-6

Chemical Formula: C18H12N2O9

Exact Mass: 400.0543

Molecular Weight: 400.29

Elemental Analysis: C, 54.01; H, 3.02; N, 7.00; O, 35.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
IUPAC/Chemical Name
2-hydroxy-5-(7-hydroxy-8-methyl-6-nitro-2-oxo-2H-chromene-3-carboxamido)benzoic acid
InChi Key
DOLJMUVMVVSXRX-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H12N2O9/c1-7-14(22)12(20(27)28)5-8-4-11(18(26)29-15(7)8)16(23)19-9-2-3-13(21)10(6-9)17(24)25/h2-6,21-22H,1H3,(H,19,23)(H,24,25)
SMILES Code
O=C(O)C1=CC(NC(C2=CC3=CC([N+]([O-])=O)=C(O)C(C)=C3OC2=O)=O)=CC=C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 400.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qi W, Zhao Q, Liu H, Jiang J, Chen X, Hu P. Determination of nicousamide in human plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2013 Apr 15;77:158-62. doi: 10.1016/j.jpba.2013.01.025. Epub 2013 Jan 26. PubMed PMID: 23416370. 2: Zhang S, Li H, Li Y, Zhang F, Liu Y, Chen X. Nicousamide normalizes renovascular hypertension in two-kidney one-clip hypertensive rats. Biomed Rep. 2013 Jan;1(1):89-92. Epub 2012 Oct 22. PubMed PMID: 24648900; PubMed Central PMCID: PMC3956876. 3: Li H, Zhang Y, Wang H, Zheng X, Chen X. Nicousamide blocks the effects of advanced glycation end products on renal cells. Eur J Pharmacol. 2012 Jan 15;674(2-3):455-9. doi: 10.1016/j.ejphar.2011.06.056. Epub 2011 Jul 13. PubMed PMID: 21763303. 4: Sheng L, Hu JP, Chen H, Li Y. [Metabolism of nicousamide in rat and human liver in vitro]. Yao Xue Xue Bao. 2008 Sep;43(9):912-6. Chinese. PubMed PMID: 19048781. 5: Zhang S, Wang D, Xue N, Lai F, Ji M, Jin J, Chen X. Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling. Am J Transl Res. 2017 Jan 15;9(1):115-125. eCollection 2017 Jan 15. PubMed PMID: 28123638; PubMed Central PMCID: PMC5250708. 6: Sheng L, Chen H, Li Y. A HPLC method for determination of nicousamide in dog plasma and its application to pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1;854(1-2):99-103. Epub 2007 Apr 13. PubMed PMID: 17452131. 7: Zhang S, Li Y, Li H, Zheng X, Chen X. Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. Biomed Rep. 2013 Jan;1(1):34-40. Epub 2012 Sep 25. PubMed PMID: 24648890; PubMed Central PMCID: PMC3956899.