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MedKoo Cat#: 528512 | Name: EO-122

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EO-122, also known as PFS-1144, is a calcium channel antagonist and sodium channel antagonist potentially for the treatment of arrhythmia.

Chemical Structure

EO-122
EO-122
CAS#23581-62-6

Theoretical Analysis

MedKoo Cat#: 528512

Name: EO-122

CAS#: 23581-62-6

Chemical Formula: C16H23ClN2O

Exact Mass:

Molecular Weight: 294.82

Elemental Analysis: C, 65.18; H, 7.86; Cl, 12.02; N, 9.50; O, 5.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
23581-62-6 (HCl); 69267-68-1 (free)
Synonym
EO-122; EO 122; EO122; EO-122 free; PFS-1144; PFS 1144; PFS1144
IUPAC/Chemical Name
N-(2,6-dimethylphenyl)quinuclidine-3-carboxamide hydrochloride
InChi Key
GTSRHNPCDKADLH-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H22N2O.ClH/c1-11-4-3-5-12(2)15(11)17-16(19)14-10-18-8-6-13(14)7-9-18;/h3-5,13-14H,6-10H2,1-2H3,(H,17,19);1H
SMILES Code
O=C(C1CN2CCC1CC2)NC3=C(C)C=CC=C3C.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 294.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Oppenheimer E, Harel G, Lipinsky D, Sarne Y. EO-199, a specific antagonist of antiarrhythmic drugs: assessment by binding experiments and in vivo studies. Life Sci. 1991;48(10):977-85. PubMed PMID: 2000027. 2: Oppenheimer E, Meiri H, Ori Y. The specific binding of [3H]EO-122, a radiolabeled class I antiarrhythmic drug to rat heart membranes. J Mol Cell Cardiol. 1989 Feb;21(2):223-30. Erratum in: J Mol Cell Cardiol 1989 Dec;21(12):1356. PubMed PMID: 2545887. 3: Marrer S. [Molecular modeling of anti-arrhythmia agents in class Ia and Ib--model conceptions of different binding receptors]. Pharm Acta Helv. 1989;64(12):338-44. German. PubMed PMID: 2616583. 4: Binah O, Gilat E, Rubinstein I, Oppenheimer E. Electrophysiological effects of a novel antiarrhythmic drug, EO-122, on guinea pig ventricular muscle and isolated myocytes. J Cardiovasc Pharmacol. 1987 Sep;10(3):301-8. PubMed PMID: 2444778. 5: Oppenheimer E, Kaplinsky E, Kariv N, Bruckstein R, Cohen S. A preclinical study of EO-122, a new lidocaine-like antiarrhythmic drug. Angiology. 1980 Jun;31(6):410-26. PubMed PMID: 7416554.