Noxytiolin | CAS#15599-39-0

MedKoo Cat#: 329623 | Name: Noxytiolin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Noxytiolin an anti-infective used for irrigation of the peritoneum.

Chemical Structure

Noxytiolin

CAS#15599-39-0

Theoretical Analysis

MedKoo Cat#: 329623

Name: Noxytiolin

CAS#: 15599-39-0

Chemical Formula: C3H8N2OS

Exact Mass: 120.0357

Molecular Weight: 120.17

Elemental Analysis: C, 29.99; H, 6.71; N, 23.31; O, 13.31; S, 26.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Noxytiolin; Noxythioline; Noxytioline; Noxyflex; Gynaflex.

IUPAC/Chemical Name

1-Hydroxymethyl-3-methyl-2-thiourea

InChi Key

JLMHZVYLAQPMOZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C3H8N2OS/c1-4-3(7)5-2-6/h6H,2H2,1H3,(H2,4,5,7)

SMILES Code

CNC(NCO)=S

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 120.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gilmore OJ, Reid C. Noxytiolin and peritoneal adhesion formation. Br J Surg. 1976 Dec;63(12):978-80. PubMed PMID: 1034491. 2: Carbasse D, Régnier C, Berthet J, Watrelot A, Racinet C. [Prevention of peritoneal adhesions. An experimental study using noxytiolin (author's transl)]. J Gynecol Obstet Biol Reprod (Paris). 1981;10(5):425-9. French. PubMed PMID: 6798098. 3: King DW, Gurry JF, Brooke BN. The effect of noxytiolin in experimental peritonitis. Br J Surg. 1975 Aug;62(8):645-6. PubMed PMID: 1174808. 4: Garrett MJ, Arthur W. A study of the efficacy of noxytiolin instillation as adjunctive to radiotherapy in carcinoma of the bladder: a clinical trial. Clin Radiol. 1981 Mar;32(2):237-9. PubMed PMID: 6783363. 5: Gurry JF, King DW, Rutter KP, Brooke BN. A controlled trial of intraperitoneal noxytiolin in perforated appendicitis. Br J Surg. 1976 May;63(5):400-1. PubMed PMID: 773484. 6: Desai S, Jamieson CW. Intraperitoneal noxytiolin as an experimental chemotherapeutic agent. Br J Surg. 1973 May;60(5):350-1. PubMed PMID: 4706478. 7: Bonnar J, Bruce LG, Low RA. Noxytiolin (Gynaflex) in the preoperative preparation of the vagina. J Obstet Gynaecol Br Commonw. 1969 Sep;76(9):850-2. PubMed PMID: 4898653. 8: MacFarlane TW, Colquhoun NK, Kennedy GD, McLundie AC. Noxytiolin...a new medicament for infected root canals. Glasg Dent J. 1970-1971 Winter;11(1):24-7. PubMed PMID: 5281271. 9: Jamieson CW, Irvine WT. Cytotoxic effects of noxytiolin on human tumour cells in culture. Br J Surg. 1970 Nov;57(11):863. PubMed PMID: 5488700. 10: Jamieson CW. Inhibition of the growth of tumour cells in culture by noxytiolin. Br J Surg. 1972 Feb;59(2):108-9. PubMed PMID: 4137729. 11: Debruyne D, Moulin MA, Bricard H, Bigot MC. Liquid chromatographic determination of noxytiolin and 1-methyl-2-thiourea in serum: application to pharmacokinetic studies in rabbits and humans. J Pharm Sci. 1985 Feb;74(2):224-6. PubMed PMID: 3921689. 12: Platt J, Jones RA, Bucknall RA. Intraperitoneal antiseptics in experimental bacterial peritonitis. Br J Surg. 1984 Aug;71(8):626-8. PubMed PMID: 6331561. 13: Platt J, Bucknall RA. An experimental evaluation of antiseptic wound irrigation. J Hosp Infect. 1984 Jun;5(2):181-8. PubMed PMID: 6205058. 14: Atterwill CK, Hillier G. Comparative studies on the effect of noxythiolin and other thioureas on the thyroid using in vitro and in vivo models of thyroid function. Food Chem Toxicol. 1991 May;29(5):355-9. PubMed PMID: 2060892. 15: Gilmore OJ. A reappraisal of the use of antiseptics in surgical practice. Ann R Coll Surg Engl. 1977 Mar;59(2):93-103. Review. PubMed PMID: 320934; PubMed Central PMCID: PMC2491732. 16: Jones MA, Hasan A. Controlled trial of intravesical noxythiolin in the prevention of infection following outflow tract surgery. Br J Urol. 1988 Oct;62(4):311-4. PubMed PMID: 3142635. 17: Elliott TS, Reid L, Rao GG, Rigby RC, Woodhouse K. Bladder irrigation or irritation? Br J Urol. 1989 Oct;64(4):391-4. PubMed PMID: 2510901. 18: George RH, Healing DE. Susceptibility of bacteroides to noxythiolin. Br Med J. 1977 Dec 3;2(6100):1478-9. PubMed PMID: 589283; PubMed Central PMCID: PMC1632631. 19: Gorman SP, McCafferty DF, Woolfson AD, Anderson L. Decrease in adherence of bacteria and yeasts to human mucosal epithelial cells by noxythiolin in vitro. J Appl Bacteriol. 1986 Apr;60(4):311-7. PubMed PMID: 3087930. 20: Brearley S, George RH. The rate of antimicrobial action of noxythiolin and taurolin. J Hosp Infect. 1980 Sep;1(3):201-9. PubMed PMID: 6182213.