MedKoo Cat#: 408155 | Name: NOTA-FAPI-4
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NOTA-FAPI-4 is an analogue of FAPI-04 and a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI-4 is useful in the diagnosis or treatment of a disease characterized by overexpression of fibroblast activation protein (FAP). NOTA-FAPI-4 can be used as a PET tracer for detection of diseases or disorders related to fibroblast activation protein.

Chemical Structure

NOTA-FAPI-4
NOTA-FAPI-4
CAS#2374782-03-1

Theoretical Analysis

MedKoo Cat#: 408155

Name: NOTA-FAPI-4

CAS#: 2374782-03-1

Chemical Formula: C36H47F2N9O8

Exact Mass: 771.3516

Molecular Weight: 771.82

Elemental Analysis: C, 56.02; H, 6.14; F, 4.92; N, 16.33; O, 16.58

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 Ready to Ship
5mg USD 950.00 Ready to Ship
10mg USD 1,650.00 Ready to Ship
25mg USD 2,950.00 Ready to Ship
50mg USD 5,250.00 Ready to Ship
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Related CAS #
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Synonym
NOTA-FAPI-4; NOTA-FAPI-04; NTFAPI; NOTA-FAPI
IUPAC/Chemical Name
(S)-2,2'-(7-(2-(4-(3-((4-((2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid
InChi Key
XQARGGQZFNOLDH-SANMLTNESA-N
InChi Code
InChI=1S/C36H47F2N9O8/c37-36(38)19-26(20-39)47(25-36)31(48)21-41-35(54)28-4-5-40-30-3-2-27(18-29(28)30)55-17-1-6-42-13-15-46(16-14-42)32(49)22-43-7-9-44(23-33(50)51)11-12-45(10-8-43)24-34(52)53/h2-5,18,26H,1,6-17,19,21-25H2,(H,41,54)(H,50,51)(H,52,53)/t26-/m0/s1
SMILES Code
O=C(C1=CC=NC2=CC=C(C=C21)OCCCN3CCN(CC3)C(CN4CCN(CCN(CC4)CC(O)=O)CC(O)=O)=O)NCC(N5CC(F)(C[C@@]5([H])C#N)F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 771.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Wang S, Zhou X, Xu X, Ding J, Liu S, Hou X, Li N, Zhu H, Yang Z. Clinical translational evaluation of Al18F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging. Eur J Nucl Med Mol Imaging. 2021 Dec;48(13):4259-4271. doi: 10.1007/s00259-021-05470-5. Epub 2021 Jun 24. PMID: 34165601.