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MedKoo Cat#: 528508 | Name: ORM-10921

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ORM-10921 is an α-2c adrenergic receptor antagonist potentially for the treatment of schizophrenia. In the pharmacodynamic microdialysis study, ORM-10921 was found to increase extracellular dopamine levels in prefrontal cortex in the baseline conditions. In the behavioural tests, ORM-10921 displayed potent antidepressant and antipsychotic-like effects in the forced swimming test and prepulse-inhibition models analogously with the previously reported results with structurally different α2C-selective AR antagonist JP-1302.

Chemical Structure

ORM-10921
ORM-10921
CAS#610782-82-6 (free base)

Theoretical Analysis

MedKoo Cat#: 528508

Name: ORM-10921

CAS#: 610782-82-6 (free base)

Chemical Formula: C18H23NO2

Exact Mass: 285.1729

Molecular Weight: 285.39

Elemental Analysis: C, 75.76; H, 8.12; N, 4.91; O, 11.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1308264-47-2 (HCl) 610782-82-6 (free base) 1308264-48-3 (hydrate)
Synonym
ORM-10921; ORM 10921; ORM10921
IUPAC/Chemical Name
(1S,12bS)-1-(methoxymethyl)-1-methyl-1,3,4,6,7,12b-hexahydro-2H-benzofuro[2,3-a]quinolizine
InChi Key
OCUKPFWNSAAHRP-QZTJIDSGSA-N
InChi Code
InChI=1S/C18H23NO2/c1-18(12-20-2)9-5-10-19-11-8-14-13-6-3-4-7-15(13)21-16(14)17(18)19/h3-4,6-7,17H,5,8-12H2,1-2H3/t17-,18-/m1/s1
SMILES Code
C[C@]1(COC)CCCN2CCC3=C(OC4=CC=CC=C43)[C@]12[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 285.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Uys MM, Shahid M, Sallinen J, Harvey BH. The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat. Behav Pharmacol. 2017 Feb;28(1):9-18. doi: 10.1097/FBP.0000000000000261. PubMed PMID: 27749317. 2: Uys M, Shahid M, Sallinen J, Dreyer W, Cockeran M, Harvey BH. The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:108-16. doi: 10.1016/j.pnpbp.2016.07.002. Epub 2016 Jul 2. PubMed PMID: 27381554. 3: Sallinen J, Holappa J, Koivisto A, Kuokkanen K, Chapman H, Lehtimäki J, Piepponen P, Mijatovic J, Tanila H, Virtanen R, Sirviö J, Haapalinna A. Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):239-49. doi: 10.1111/bcpt.12090. Epub 2013 Jun 20. PubMed PMID: 23718812.