Synonym
Bisdequalinium diacetate; R-199; Salvisol; Salvizol; bis-dequalinium; bisdequalinium acetate.
IUPAC/Chemical Name
12,132-dimethyl-2,14-diaza-1(4,1),13(1,4)-diquinolin-1-iumacyclotetracosaphane-11,131-diium acetate
InChi Key
IIQDCFNLLNWVKT-BGRABRFLSA-N
InChi Code
InChI=1S/C40H56N4.2C2H4O2/c1-33-31-37-35-23-15-17-25-39(35)43(33)29-21-13-9-5-3-8-12-20-28-42-38-32-34(2)44(40-26-18-16-24-36(38)40)30-22-14-10-6-4-7-11-19-27-41-37;2*1-2(3)4/h15-18,23-26,31-32H,3-14,19-22,27-30H2,1-2H3;2*1H3,(H,3,4)/b41-37+,42-38+;;
SMILES Code
CC1=CC(NCCCCCCCCCC2)=C(C=CC=C3)C3=[N+]1CCCCCCCCCCNC4=C(C=CC=C5)C5=[N+]2C(C)=C4.CC([O-])=O.CC([O-])=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
713.02
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Theodoropoulos D, Rova A, Smith JR, Barbu E, Calabrese G, Vizirianakis IS, Tsibouklis J, Fatouros DG. Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the therapeutic delivery of the dequalinium salt of bis-nido-carborane. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6161-6. doi: 10.1016/j.bmcl.2013.09.003. Epub 2013 Sep 10. PubMed PMID: 24080462.
2: Haikel Y, Gorce F, Allemann C, Voegel JC. In vitro efficiency of endodontic irrigation solutions on protein desorption. Int Endod J. 1994 Jan;27(1):16-20. PubMed PMID: 7806406.
3: Díaz Artigas C, Perrone JR. [Comparative study of chelates]. An Fac Odontol. 1990 Dec;(26):63-7. Spanish. PubMed PMID: 2134733.
4: Rodrigues HH, Semprini M, Ignacio E. [Quantification of the acute toxicity of antiseptic endodontic solutions with a hemolysis screening test]. Rev Esp Endodoncia. 1988 Sep;6(2):35-43. Spanish. PubMed PMID: 3270099.
5: Spångberg L, Safavi KE, Kaufman A, Pascon EA. Antimicrobial and toxic effect in vitro of a bisdequalinium acetate solution for endodontic use. J Endod. 1988 Apr;14(4):175-8. PubMed PMID: 3268636.
6: Spangberg L, Pascon EA, Kaufman AY, Safavi K. Tissue irritating properties of bis-dequalinium acetate solutions for endodontic use. J Endod. 1988 Feb;14(2):88-97. PubMed PMID: 3162945.
7: Görgül G, Başbuğ N, Omürlü H. [An evaluation of the antibacterial effectiveness of bisdequalinium acetate and sodium hypochlorite]. Mikrobiyol Bul. 1987 Oct;21(4):289-95. Turkish. PubMed PMID: 3141752.
8: Aron MC. [Cytotoxic potential of two canal irrigation agents (Part 3)]. Rev Fr Endod. 1987 Jun;6(2):39-60. French. PubMed PMID: 3482923.
9: Aron MC. [Cytotoxic potential of two canal irrigation agents (Part 2)]. Rev Fr Endod. 1987 Mar;6(1):45-59. French. PubMed PMID: 3482921.
10: Trykowski J, Gajewski D. [Evaluation of the tissue tolerance of a new endodontic agent for disinfection of root canals]. Czas Stomatol. 1986 Aug;39(8):499-503. Polish. PubMed PMID: 3477390.
11: Kaufman AY, Greenberg I. Comparative study of the configuration and the cleanliness level of root canals prepared with the aid of sodium hypochlorite and bis-dequalinium-acetate solutions. Oral Surg Oral Med Oral Pathol. 1986 Aug;62(2):191-7. PubMed PMID: 3462616.
12: Aron MC. [Cytotoxic potential of 2 root canal irrigating agents (1)]. Rev Fr Endod. 1986 Jun;5(2):13-26. French. PubMed PMID: 3474727.
13: Trykowski J, Wojtowicz A. [Evaluation of the cytotoxicity of metronidazole and salvizol in relation to their use in endodontics]. Czas Stomatol. 1986 Jan;39(1):1-6. Polish. PubMed PMID: 3467904.
14: Kaufman AY, Bruyer L, Shaked A. A comparison study between chlorhexidine and bisdequalinium acetate in solution and lozenge form as a plaque-preventing agent. Quintessence Int Dent Dig. 1984 Nov;15(11):1179-84. PubMed PMID: 6597468.
15: Goldberg F, Massone EJ, Spielberg C. [Comparative study of the effect of EDTAC and Salvizol on the walls of instrumented root canals. Analysis using scanning electron microscopy]. Rev Esp Endodoncia. 1984 May;2(1):17-20. Spanish. PubMed PMID: 6443530.
16: Koskinen KP, Meurman JH, Stenvall H. Appearance of chemically treated root canal walls in the scanning electron microscope. Scand J Dent Res. 1980 Dec;88(6):505-12. PubMed PMID: 6264586.
17: Koskinen KP, Stenvall H, Uitto VJ. Dissolution of bovine pulp tissue by endodontic solutions. Scand J Dent Res. 1980 Oct;88(5):406-11. PubMed PMID: 6258220.
18: Koskinen KP, Meurman JH, Stenvall H. Appearance of chemically treated root canal walls in the scanning electron microscope. Scand J Dent Res. 1980 Oct;88(5):397-405. PubMed PMID: 6258219.
19: Biesterfeld RC, Taintor JF. A comparison of periapical seals of root canals with RC-Prep or Salvizol. Oral Surg Oral Med Oral Pathol. 1980 Jun;49(6):532-7. PubMed PMID: 6770314.
20: NIEMAND HG, NIEMAND S. [SPECIAL SALVIZOL PREPARATIONS IN VETERINARY MEDICINE FOR SMALL ANIMALS]. Berl Munch Tierarztl Wochenschr. 1965 May 15;78:186-8. German. PubMed PMID: 14344177.
