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MedKoo Cat#: 528426 | Name: Amitivir

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amitivir, also known as LY-217896, is an inosine monophosphate dehydrogenase inhibitor potentially for the treatment of influenza virus infections. Amitivir inhibited the replication of dividing MDCK cells. Amitivir was associated with asymptomatic rises in serum uric acid levels and was ineffective in modifying the virologic or clinical course of experimental influenza A (H1N1) virus infection.

Chemical Structure

Amitivir
Amitivir
CAS#111393-84-1 (free base)

Theoretical Analysis

MedKoo Cat#: 528426

Name: Amitivir

CAS#: 111393-84-1 (free base)

Chemical Formula: C3H2N4S

Exact Mass: 126.0000

Molecular Weight: 126.14

Elemental Analysis: C, 28.57; H, 1.60; N, 44.42; S, 25.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
111393-93-2 (sodium) 111393-84-1 (free base)
Synonym
Amitivir; LY-217896; LY 217896; LY217896
IUPAC/Chemical Name
N-(1,3,4-thiadiazol-2-yl)cyanamide
InChi Key
YUCHAYRHHXJNQK-UHFFFAOYSA-N
InChi Code
InChI=1S/C3H2N4S/c4-1-5-3-7-6-2-8-3/h2H,(H,5,7)
SMILES Code
N#CNC1=NN=CS1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 126.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Herman JL, Chay SH. Quantitative whole-body autoradiography in pregnant rabbits to determine fetal exposure of potential teratogenic compounds. J Pharmacol Toxicol Methods. 1998 Feb;39(1):29-33. PubMed PMID: 9596145. 2: Bonate PL, Peyton A. Uptake and biodisposition of 2-ylcyanamide-1,3,4-thiadiazole (LY217896) by red blood cells. Biopharm Drug Dispos. 1995 Mar;16(2):151-67. PubMed PMID: 7780048. 3: Hayden FG, Tunkel AR, Treanor JJ, Betts RF, Allerheiligen S, Harris J. Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans. Antimicrob Agents Chemother. 1994 May;38(5):1178-81. PubMed PMID: 8067760; PubMed Central PMCID: PMC188174. 4: Ehlhardt WJ, Wheeler WJ, Breau AP, Chay SH, Birch GM. Biotransformation of the antiviral agent 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and characteristics of a mesoionic ribose metabolite. Drug Metab Dispos. 1993 Jan-Feb;21(1):162-70. PubMed PMID: 8095212. 5: Colacino JM, DeLong DC, Nelson JR, Spitzer WA, Tang J, Victor F, Wu CY. Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt. Antimicrob Agents Chemother. 1990 Nov;34(11):2156-63. PubMed PMID: 2073106; PubMed Central PMCID: PMC172017. 6: Wyde PR, Ambrose MW, Meyer HL, Gilbert BE. Toxicity and antiviral activity of LY253963 against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats. Antiviral Res. 1990 Oct-Nov;14(4-5):237-47. PubMed PMID: 1965110. 7: Hayden FG, Rollins BS, Hay AJ. Anti-influenza virus activity of the compound LY253963. Antiviral Res. 1990 Jul;14(1):25-38. PubMed PMID: 2080866.