MedKoo Cat#: 528804 | Name: TSR-011-isomer

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TSR011-isomer, an isomer of TSR-011 or Belizatinib, is a TrKA/ALK inhibitor potentially for the treatment of solid tumours and lymphoma.

Chemical Structure

TSR-011-isomer
TSR-011-isomer
CAS#1388225-79-3 (TSR-011 isomer)

Theoretical Analysis

MedKoo Cat#: 528804

Name: TSR-011-isomer

CAS#: 1388225-79-3 (TSR-011 isomer)

Chemical Formula: C33H43F2N5O3

Exact Mass: 595.3334

Molecular Weight: 595.73

Elemental Analysis: C, 66.53; H, 7.28; F, 6.38; N, 11.76; O, 8.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
TSR-011 isomer; TSR011 isomer; TSR 011 isomer; Belizatinib isomer
IUPAC/Chemical Name
3,5-difluoro-N-((E)-6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)benzamide
InChi Key
GZYCQQBRSRIFII-JAQLMMITSA-N
InChi Code
InChI=1S/C33H43F2N5O3/c1-20(2)36-30(41)22-6-8-27(9-7-22)40-29-15-21(19-39-13-11-24(12-14-39)33(3,4)43)5-10-28(29)37-32(40)38-31(42)23-16-25(34)18-26(35)17-23/h5,10,15-18,20,22,24,27,43H,6-9,11-14,19H2,1-4H3,(H,36,41)(H,37,38,42)/t22-,27+
SMILES Code
O=C(/N=C1NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N\1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC(F)=CC(F)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 595.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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