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MedKoo Cat#: 532188 | Name: ML 10375

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML 10375 is a 5-HT4 receptor antagonist.

Chemical Structure

ML 10375
ML 10375
CAS#174008-52-7

Theoretical Analysis

MedKoo Cat#: 532188

Name: ML 10375

CAS#: 174008-52-7

Chemical Formula: C17H25ClN2O3

Exact Mass: 340.1554

Molecular Weight: 340.85

Elemental Analysis: C, 59.91; H, 7.39; Cl, 10.40; N, 8.22; O, 14.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ML 10375; ML 10375 ; ML10375 .
IUPAC/Chemical Name
2-(3,5-dimethylpiperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
InChi Key
BUEFUOFMOXJXAR-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H25ClN2O3/c1-11-6-12(2)10-20(9-11)4-5-23-17(21)13-7-14(18)15(19)8-16(13)22-3/h7-8,11-12H,4-6,9-10,19H2,1-3H3
SMILES Code
O=C(OCCN1CC(C)CC(C)C1)C2=CC(Cl)=C(N)C=C2OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 340.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Derangeon M, Bozon V, Defamie N, Peineau N, Bourmeyster N, Sarrouilhe D, Argibay JA, Hervé JC. 5-HT4 and 5-HT2 receptors antagonistically influence gap junctional coupling between rat auricular myocytes. J Mol Cell Cardiol. 2010 Jan;48(1):220-9. doi: 10.1016/j.yjmcc.2009.07.005. PubMed PMID: 19615378. 2: Rivail L, Giner M, Gastineau M, Berthouze M, Soulier JL, Fischmeister R, Lezoualc'h F, Maigret B, Sicsic S, Berque-Bestel I. New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket. Br J Pharmacol. 2004 Oct;143(3):361-70. PubMed PMID: 15351779; PubMed Central PMCID: PMC1575351. 3: Blondel O, Gastineau M, Langlois M, Fischmeister R. The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor. Br J Pharmacol. 1998 Oct;125(4):595-7. PubMed PMID: 9831890; PubMed Central PMCID: PMC1571008.