MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 532187 | Name: ML-10302 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML-10302 HCl is a potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively).

Chemical Structure

ML-10302 HCl
ML-10302 HCl
CAS#186826-17-5

Theoretical Analysis

MedKoo Cat#: 532187

Name: ML-10302 HCl

CAS#: 186826-17-5

Chemical Formula: C15H22Cl2N2O3

Exact Mass:

Molecular Weight: 349.25

Elemental Analysis: C, 51.59; H, 6.35; Cl, 20.30; N, 8.02; O, 13.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
186826-17-5 (ML-10302 HCl); 148868-55-7 (ML-10302).
Synonym
ML-10302 HCl; ML-10302; ML 10302; ML10302.
IUPAC/Chemical Name
4-Amino-5-chloro-2-methoxybenzoic acid 2-(1-piperidinyl)ethyl ester hydrochloride
InChi Key
HBLRTSYSGOFQCK-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H21ClN2O3.ClH/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18;/h9-10H,2-8,17H2,1H3;1H
SMILES Code
O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 349.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Godínez-Chaparro B, López-Santillán FJ, Orduña P, Granados-Soto V. Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT₄, 5-HT₆ and 5-HT₇ receptors. Neuroscience. 2012 Oct 11;222:379-91. doi: 10.1016/j.neuroscience.2012.07.008. PubMed PMID: 22796074. 2: Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V. Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia. Pain. 2011 Mar;152(3):687-97. doi: 10.1016/j.pain.2010.12.020. PubMed PMID: 21239110. 3: Russo O, Cachard-Chastel M, Rivière C, Giner M, Soulier JL, Berthouze M, Richard T, Monti JP, Sicsic S, Lezoualc'h F, Berque-Bestel I. Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease. J Med Chem. 2009 Apr 23;52(8):2214-25. doi: 10.1021/jm801327q. PubMed PMID: 19334715. 4: Russo O, Berthouze M, Giner M, Soulier JL, Rivail L, Sicsic S, Lezoualc'h F, Jockers R, Berque-Bestel I. Synthesis of specific bivalent probes that functionally interact with 5-HT(4) receptor dimers. J Med Chem. 2007 Sep 6;50(18):4482-92. PubMed PMID: 17676726. 5: Cachard-Chastel M, Lezoualc'h F, Dewachter I, Deloménie C, Croes S, Devijver H, Langlois M, Van Leuven F, Sicsic S, Gardier AM. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007 Apr;150(7):883-92. PubMed PMID: 17325649; PubMed Central PMCID: PMC2013878. 6: Soulier JL, Russo O, Giner M, Rivail L, Berthouze M, Ongeri S, Maigret B, Fischmeister R, Lezoualc'h F, Sicsic S, Berque-Bestel I. Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies. J Med Chem. 2005 Oct 6;48(20):6220-8. PubMed PMID: 16190749. 7: De Ponti F, Crema F, Moro E, Nardelli G, Croci T, Frigo GM. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol Motil. 2001 Dec;13(6):543-53. PubMed PMID: 11903915. 8: Curtet S, Soulier JL, Zahradnik I, Giner M, Berque-Bestel I, Mialet J, Lezoualc'h F, Donzeau-Gouge P, Sicsic S, Fischmeister R, Langlois M. New arylpiperazine derivatives as antagonists of the human cloned 5-HT(4) receptor isoforms. J Med Chem. 2000 Oct 5;43(20):3761-9. PubMed PMID: 11020291. 9: Crema F, Modini C, Croci T, Langlois M, de Ponti F. Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. J Pharmacol Exp Ther. 1999 Mar;288(3):1045-52. PubMed PMID: 10027842. 10: Yang D, Soulier JL, Sicsic S, Mathé-Allainmat M, Brémont B, Croci T, Cardamone R, Aureggi G, Langlois M. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21. PubMed PMID: 9046352.