Related CAS #
310392-94-0 (MIN-117 free base)
Synonym
Wf-516; MIN-117; Wf516; MIN117; Wf 516; MIN 117
IUPAC/Chemical Name
1-(4-(3,4-dichlorophenyl)piperidin-1-yl)-3-((2-(5-methyl-1,3,4-oxadiazol-2-yl)benzofuran-4-yl)oxy)propan-2-ol hydrochloride
InChi Key
HRNDUKHBCUTNAL-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H25Cl2N3O4.ClH/c1-15-28-29-25(33-15)24-12-19-22(3-2-4-23(19)34-24)32-14-18(31)13-30-9-7-16(8-10-30)17-5-6-20(26)21(27)11-17;/h2-6,11-12,16,18,31H,7-10,13-14H2,1H3;1H
SMILES Code
OC(COC1=C2C=C(C3=NN=C(C)O3)OC2=CC=C1)CN4CCC(C5=CC=C(Cl)C(Cl)=C5)CC4.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
538.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: El Mansari M, Blier P. In vivo electrophysiological assessment of the putative antidepressant Wf-516 in the rat raphe dorsalis, locus coeruleus and hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):351-61. PubMed PMID: 18060386.
2: Saijo T, Maeda J, Okauchi T, Maeda J, Morio Y, Kuwahara Y, Suzuki M, Goto N, Fukumura T, Suhara T, Higuchi M. Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain. PLoS One. 2012;7(8):e42589. doi: 10.1371/journal.pone.0042589. PubMed PMID: 22880045; PubMed Central PMCID: PMC3413639.
3: Saijo T, Maeda J, Okauchi T, Maeda J, Morio Y, Kuwahara Y, Suzuki M, Goto N, Suzuki K, Higuchi M, Suhara T. Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter. Int J Neuropsychopharmacol. 2009 Sep;12(8):1021-32. doi: 10.1017/S1461145709000042. PubMed PMID: 19236731.
