MedKoo Cat#: 462110 | Name: Chlormerodrin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlormerodrin is urea in which one of the hydrogens is substituted by a 3-chloromercury-2-methoxyprop-1-yl group. It was formerly used as a diuretic, but more potent and less toxic drugs are now available. Its radiolabelled ((197)Hg, (203)Hg) forms were used in diagnostic aids in renal imaging and brain scans. It has a role as a diuretic and a diagnostic agent. It is an organomercury compound and a member of ureas.

Chemical Structure

Chlormerodrin
Chlormerodrin
CAS#62-37-3

Theoretical Analysis

MedKoo Cat#: 462110

Name: Chlormerodrin

CAS#: 62-37-3

Chemical Formula: C5H11ClHgN2O2

Exact Mass: 368.0215

Molecular Weight: 367.20

Elemental Analysis: C, 16.36; H, 3.02; Cl, 9.65; Hg, 54.63; N, 7.63; O, 8.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Chlormerodrin; Katonil; Clormerodrina; Mercloran; Merculest; Chlormerodrinum; Percapyl; Promeranum; Neohydrin; Merilid
IUPAC/Chemical Name
Mercury, chloro(2-methoxy-3-ureidopropyl)-
InChi Key
BJFGVYCULWBXKF-UHFFFAOYSA-M
InChi Code
InChI=1S/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1
SMILES Code
O=C(N)NCC(OC)C[Hg]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: The Quantitative Measurement of Tubular Chlormerodrin Binding as an Index of Renal Function: A Study of 400 Cases D. L. Tabern, J. Kearney, H. Sohn Can Med Assoc J. 1970 Sep 26; 103(6): 601–607. PMCID: PMC1930528 2: Localization of Erythrocyte Membrane Sulfhydryl Groups Essential for Glucose Transport. J. Vansteveninck, R. I. Weed, A. Rothstein. J Gen Physiol. 1965 Mar 1; 48(4): 617–632. doi: 10.1085/jgp.48.4.617. PMCID: PMC2195434 3: The kidney in hypertension: studies with radioactive chlormerodrin. R. Secker-Walker. Proc R Soc Med. 1967 Jan; 60(1): 41–44. PMCID: PMC1901408 4: The mechanism of action of mercurial diuretics in rats; the metabolism of 203hg-labelled chlormerodrin. T. W. Clarkson, A. Rothstein, R. Sutherland. Br J Pharmacol Chemother. 1965 Feb; 24(1): 1–13. doi: 10.1111/j.1476-5381.1965.tb02075.x. PMCID: PMC1704042 5: THE DISTRIBUTION OF CHLORMERODRIN (NEOHYDRIN®) IN TISSUES OF THE RAT AND DOG. R. R. M. Borghgraef, R. F. Pitts. J Clin Invest. 1956 Jan; 35(1): 31–37. doi: 10.1172/JCI103249. PMCID: PMC438775 6: Localization of kidney for renal biopsy using chlormerodrin-203Hg. L. Reese, D. Joshi. Can Med Assoc J. 1968 Aug 10; 99(6): 245–247. PMCID: PMC1924393 7: Chlormerodrin: Clinical Effectiveness and Absence of Toxicity in Congestive Heart Failure. William A. Leff, Harvey E. Nussbaum. Br Med J. 1959 Apr 4; 1(5126): 883–889. doi: 10.1136/bmj.1.5126.883. PMCID: PMC1992943 8: PLASMA REGRESSION, DISTRIBUTION AND EXCRETION OF RADIOMERCURY IN RELATION TO DIURESIS FOLLOWING THE INTRAVENOUS ADMINISTRATION OF Hg203 LABELLED CHLORMERODRIN TO THE DOG R. R. M. Borghgraef, R. H. Kessler, R. F. Pitts, M. E. Parks, W. Van Woert, M. B. MacLeod. J Clin Invest. 1956 Sep; 35(9): 1055–1066. doi: 10.1172/JCI103351. PMCID: PMC441680 9: The Role of Radioisotope Renal Scanning in the Assessment of Renal Disease. Leonard Rosenthall. Can Med Assoc J. 1964 Apr 25; 90(17): 999–1004. PMCID: PMC1922682 10: Mercury 197 chlormerodrin in the diagnosis of intraocular tumours. J M Cappin, D P Greaves. Br J Ophthalmol. 1972 Nov; 56(11): 805–811. doi: 10.1136/bjo.56.11.805. PMCID: PMC1214748