1: Phyo AP, Jittamala P, Nosten FH, Pukrittayakamee S, Imwong M, White NJ, Duparc S, Macintyre F, Baker M, Möhrle JJ. Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial. Lancet Infect Dis. 2016 Jan;16(1):61-9. doi: 10.1016/S1473-3099(15)00320-5. PubMed PMID: 26448141; PubMed Central PMCID: PMC4700386.
2: McCarthy JS, Baker M, O'Rourke P, Marquart L, Griffin P, Hooft van Huijsduijnen R, Möhrle JJ. Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers. J Antimicrob Chemother. 2016 Sep;71(9):2620-7. doi: 10.1093/jac/dkw174. PubMed PMID: 27272721; PubMed Central PMCID: PMC4992851.
3: Kim HS, Hammill JT, Guy RK. Seeking the Elusive Long-Acting Ozonide: Discovery of Artefenomel (OZ439). J Med Chem. 2017 Mar 15. doi: 10.1021/acs.jmedchem.7b00299. [Epub ahead of print] PubMed PMID: 28296396.
4: Jourdan J, Matile H, Reift E, Biehlmaier O, Dong Y, Wang X, Mäser P, Vennerstrom JL, Wittlin S. Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel). ACS Infect Dis. 2016 Jan 8;2(1):54-61. PubMed PMID: 26819968; PubMed Central PMCID: PMC4718528.
5: Dong Y, Wang X, Kamaraj S, Bulbule VJ, Chiu FC, Chollet J, Dhanasekaran M, Hein CD, Papastogiannidis P, Morizzi J, Shackleford DM, Barker H, Ryan E, Scheurer C, Tang Y, Zhao Q, Zhou L, White KL, Urwyler H, Charman WN, Matile H, Wittlin S, Charman SA, Vennerstrom JL. Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439). J Med Chem. 2017 Jan 18. doi: 10.1021/acs.jmedchem.6b01586. [Epub ahead of print] PubMed PMID: 28052200.
6: Rosenthal PJ. Artefenomel: a promising new antimalarial drug. Lancet Infect Dis. 2016 Jan;16(1):6-8. doi: 10.1016/S1473-3099(15)00343-6. PubMed PMID: 26448142.
7: White NJ. Can new treatment developments combat resistance in malaria? Expert Opin Pharmacother. 2016 Jul;17(10):1303-7. doi: 10.1080/14656566.2016.1187134. PubMed PMID: 27191998.
8: Yang T, Xie SC, Cao P, Giannangelo C, McCaw J, Creek DJ, Charman SA, Klonis N, Tilley L. Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4501-10. doi: 10.1128/AAC.00574-16. PubMed PMID: 27161632; PubMed Central PMCID: PMC4958167.