ME0328 is an inhibitor of PARP-3 (IC50 = 0.89 μM). ME0328 displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). ME0328 also enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells.
MedKoo Cat#: 532177
Name: ME0328
CAS#: 1445251-22-8
Chemical Formula: C19H19N3O2
Exact Mass: 321.1477
Molecular Weight: 321.38
Elemental Analysis: C, 71.01; H, 5.96; N, 13.08; O, 9.96
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 12.0 | 37.34 | |
| DMF:PBS (pH 7.2) (1:1) | 0.5 | 1.56 | |
| DMSO | 52.0 | 161.80 | |
| Ethanol | 0.2 | 0.62 |
The following data is based on the product molecular weight 321.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
