MedKoo Cat#: 532151 | Name: LY233053

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY233053 is a structurally novel, potent and selective competitive N-methyl-D-aspartate receptor antagonist.

Chemical Structure

LY233053
LY233053
CAS#125546-04-5

Theoretical Analysis

MedKoo Cat#: 532151

Name: LY233053

CAS#: 125546-04-5

Chemical Formula: C8H13N5O2

Exact Mass: 211.1069

Molecular Weight: 211.23

Elemental Analysis: C, 45.49; H, 6.20; N, 33.16; O, 15.15

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
LY233053; LY-233053 LY 233053.
IUPAC/Chemical Name
(2R,4S)-4-(1H-1,2,3,4-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid
InChi Key
FAAVTENFCLADRE-NTSWFWBYSA-N
InChi Code
InChI=1S/C8H13N5O2/c14-8(15)6-3-5(1-2-9-6)4-7-10-12-13-11-7/h5-6,9H,1-4H2,(H,14,15)(H,10,11,12,13)/t5-,6+/m0/s1
SMILES Code
O=C([C@@H]1NCC[C@H](CC2=NN=NN2)C1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 211.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Madden KP, Clark WM, Kochhar A, Zivin JA. Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. J Neurosurg. 1992 Jan;76(1):106-10. PubMed PMID: 1727148. 2: Schoepp DD, Ornstein PL, Leander JD, Lodge D, Salhoff CR, Zeman S, Zimmerman DM. Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action. J Pharmacol Exp Ther. 1990 Dec;255(3):1301-8. PubMed PMID: 2148188. 3: Ornstein PL, Schoepp DD, Leander JD, Wong T, Zimmerman DM, Lodge D. LY233053: a structurally novel, potent and selective competitive N-methyl-D-aspartate receptor antagonist. Prog Clin Biol Res. 1990;361:429-33. PubMed PMID: 2149764.