Synonym
Azuletil, Egualen, Egualene
IUPAC/Chemical Name
3-Ethyl-7-isopropyl-1-azulenesulfonic acid
InChi Key
NARQSHREEUXZBT-UHFFFAOYSA-N
InChi Code
1S/C15H18O3S/c1-4-11-9-15(19(16,17)18)14-8-12(10(2)3)6-5-7-13(11)14/h5-10H,4H2,1-3H3,(H,16,17,18)
SMILES Code
c12c(S(=O)(O)=O)cc(c1cccc(c2)C(C)C)CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
278.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Iguchi M, Kakimoto K, Kuramoto T, Nakazawa K, Kubota M, Hirata Y, Fujiwara K, Harada S, Sakanaka T, Ota K, Edogawa S, Kojima Y, Nouda S, Okada T, Kawakami K, Takeuchi T, Inoue T, Higuchi K. Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial. J Clin Biochem Nutr. 2018 Mar;62(2):174-178. doi: 10.3164/jcbn.17-46. Epub 2018 Jan 11. PubMed PMID: 29610558; PubMed Central PMCID: PMC5874231.
2: Amagase K, Yoshida Y, Hara D, Murakami T, Takeuchi K. Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats. J Physiol Pharmacol. 2013 Feb;64(1):65-75. PubMed PMID: 23568973.
3: Akagi M, Matsui N, Mochizuki S, Tasaka K. Inhibitory effect of egualen sodium: a new stable derivative of azulene on histamine release from mast cell-like cells in the stomach. Pharmacology. 2001;63(4):203-9. PubMed PMID: 11729358.
4: Mochizuki S, Matsumoto M, Wakabayashi S, Kosakai K, Tomiyama A, Kishimoto S. Therapeutic effect of egualen sodium (KT1-32), a new antiulcer agent, on chronic gastritis induced by sodium taurocholate in rats. J Gastroenterol. 1996 Dec;31(6):785-92. PubMed PMID: 9027640.
