MedKoo Cat#: 407422 | Name: AR-7
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AR-7, also known as Atypical retinoid 7 , is a potent and selective enhancer of the chaperone-mediated autophagy (CMA).

Chemical Structure

AR-7
AR-7
CAS#80306-38-3

Theoretical Analysis

MedKoo Cat#: 407422

Name: AR-7

CAS#: 80306-38-3

Chemical Formula: C15H12ClNO

Exact Mass: 257.0607

Molecular Weight: 257.72

Elemental Analysis: C, 69.91; H, 4.69; Cl, 13.76; N, 5.44; O, 6.21

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
100mg USD 650.00 2 Weeks
200mg USD 1,050.00 2 Weeks
500mg USD 1,850.00 2 Weeks
1g USD 2,850.00 2 Weeks
2g USD 3,950.00 2 Weeks
5g USD 5,450.00 2 Weeks
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Related CAS #
No Data
Synonym
AR-7; AR 7; AR7; Atypical retinoid 7.
IUPAC/Chemical Name
7-Chloro-3-(p-tolyl)-2H-benzo[b][1,4]oxazine
InChi Key
MVOZLTFXYGHZPM-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H12ClNO/c1-10-2-4-11(5-3-10)14-9-18-15-8-12(16)6-7-13(15)17-14/h2-8H,9H2,1H3
SMILES Code
CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 257.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2020 Feb;16(2):347-370. doi: 10.1080/15548627.2019.1603545. Epub 2019 Apr 14. PMID: 30983487; PMCID: PMC6984454. 2. Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 May 13;184(10):2696-2714.e25. doi: 10.1016/j.cell.2021.03.048. Epub 2021 Apr 22. PMID: 33891876; PMCID: PMC8152331. 3. Anguiano J, Garner TP, Mahalingam M, Das BC, Gavathiotis E, Cuervo AM. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013 Jun;9(6):374-82. doi: 10.1038/nchembio.1230. Epub 2013 Apr 14. Erratum in: Nat Chem Biol. 2013 Nov;9(11):746. PMID: 23584676; PMCID: PMC3661710.