PRX-03140 potassium | CAS#869493-26-5 | 5-HT4 Partial Agonist

MedKoo Cat#: 529009 | Name: PRX-03140 potassium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VRX 03011, also known as NTC-942 and PRX-03140, is a 5-HT4 partial agonist potentially for the treatment of Alzheimer's disease.

Chemical Structure

PRX-03140 potassium

CAS#869493-26-5 (potassium)

Theoretical Analysis

MedKoo Cat#: 529009

Name: PRX-03140 potassium

CAS#: 869493-26-5 (potassium)

Chemical Formula: C19H26KN3O3S

Exact Mass:

Molecular Weight: 415.59

Elemental Analysis: C, 54.91; H, 6.31; K, 9.41; N, 10.11; O, 11.55; S, 7.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

869493-21-0 (free) 869493-26-5 (potassium)

Synonym

NTC-942; NTC942; NTC 942; PRX-03140; PRX-3140; PRX03140; PRX3140; PRX 03140; PRX 3140; VRX 03011; VRX 03011; VRX-03011

IUPAC/Chemical Name

potassium 7-isopropyl-6-oxo-5-((3-(piperidin-1-yl)propyl)carbamoyl)-6,7-dihydrothieno[2,3-b]pyridin-4-olate

InChi Key

JWRDEPYIIBDWDI-UHFFFAOYSA-M

InChi Code

InChI=1S/C19H27N3O3S.K/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21;/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24);/q;+1/p-1

SMILES Code

O=C(C1=C([O-])C(C=CS2)=C2N(C(C)C)C1=O)NCCCN3CCCCC3.[K+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 415.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mohler EG, Shacham S, Noiman S, Lezoualc'h F, Robert S, Gastineau M, Rutkowski J, Marantz Y, Dumuis A, Bockaert J, Gold PE, Ragozzino ME. VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux. Neuropharmacology. 2007 Sep;53(4):563-73. PubMed PMID: 17692343. 2: Johnson DE, Drummond E, Grimwood S, Sawant-Basak A, Miller E, Tseng E, McDowell LL, Vanase-Frawley MA, Fisher KE, Rubitski DM, Stutzman-Engwall KJ, Nelson RT, Horner WE, Gorczyca RR, Hajos M, Siok CJ. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3):681-91. doi: 10.1124/jpet.112.192351. PubMed PMID: 22408061. 3: Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT. 5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment. Neuropharmacology. 2011 Jul-Aug;61(1-2):69-79. doi: 10.1016/j.neuropharm.2011.02.026. PubMed PMID: 21392515.