GSK-319347A | GSK-319347 | CAS#862812-98-4

MedKoo Cat#: 407415 | Name: GSK-319347A

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-319347A is a potent and selective IKKε inhibitor (pIC50 = 7.4). GSK-319347A has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.

Chemical Structure

GSK-319347A

CAS#862812-98-4

Theoretical Analysis

MedKoo Cat#: 407415

Name: GSK-319347A

CAS#: 862812-98-4

Chemical Formula: C22H19N3O5S2

Exact Mass: 469.0766

Molecular Weight: 469.53

Elemental Analysis: C, 56.28; H, 4.08; N, 8.95; O, 17.04; S, 13.66

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 450.00	2 Weeks
10mg	USD 800.00	2 Weeks

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Related CAS #

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Synonym

GSK-319347A; GSK-319347A; GSK-319347A; CAY10576; CAY 10576; CAY-10576; IKK-3 Inhibitor IX; NSC756172; NSC 756172; NSC-756172

IUPAC/Chemical Name

5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile

InChi Key

LDTAHRLHGHFHKP-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3

SMILES Code

N#CC1=C(OCC2=CC=CC=C2S(=O)(C)=O)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 469.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bamborough P, Christopher JA, Cutler GJ, Dickson MC, Mellor GW, Morey JV, Patel CB, Shewchuk LM. 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6236-40. PubMed PMID: 16997559.