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MedKoo Cat#: 407411 | Name: EN460

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EN460 is an endoplasmic reticulum oxidoreductase (ERO1) inhibitor. EN460 showed a dose response effect on the embryos with a dose of 10 μM being significantly lethal during early embryonic development.

Chemical Structure

EN460
EN460
CAS#496807-64-8

Theoretical Analysis

MedKoo Cat#: 407411

Name: EN460

CAS#: 496807-64-8

Chemical Formula: C22H12ClF3N2O4

Exact Mass: 460.0438

Molecular Weight: 460.79

Elemental Analysis: C, 57.35; H, 2.63; Cl, 7.69; F, 12.37; N, 6.08; O, 13.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
EN460; EN-460; EN 460.
IUPAC/Chemical Name
(Z)-2-chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
InChi Key
RSLFQCNAOMQAIH-WJDWOHSUSA-N
InChi Code
InChI=1S/C22H12ClF3N2O4/c23-17-8-6-13(10-15(17)21(30)31)28-20(29)16(19(27-28)22(24,25)26)11-14-7-9-18(32-14)12-4-2-1-3-5-12/h1-11H,(H,30,31)/b16-11-
SMILES Code
O=C(O)C1=CC(N2N=C(C(F)(F)F)/C(C2=O)=C/C3=CC=C(C4=CC=CC=C4)O3)=CC=C1Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 460.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Blais JD, Chin KT, Zito E, Zhang Y, Heldman N, Harding HP, Fass D, Thorpe C, Ron D. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003. doi: 10.1074/jbc.M110.126599. PubMed PMID: 20442408; PubMed Central PMCID: PMC2898301. 2. High-content screen using Zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor In Press, Accepted Manuscript, Available online 28 February 2017 Werner J. Geldenhuys, Sadie A. Bergeron, Jackie E. Mullins, Rowaa Aljammal, Briah L. Gaasch, Wei-Chi Chen, June Yun, Lori A. Hazlehurst