Synonym
L-775,606; L 775,606; L775,606; L775606; L-775606; L 775606;
IUPAC/Chemical Name
3-[3-[4-[2-(3-fluorophenyl)ethyl]piperazin-1-yl]propyl]-5-(1,2,4-triazol-4-yl)-1H-indole
InChi Key
ZUTQCPBDRJBADG-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H29FN6/c26-22-5-1-3-20(15-22)8-10-31-13-11-30(12-14-31)9-2-4-21-17-27-25-7-6-23(16-24(21)25)32-18-28-29-19-32/h1,3,5-7,15-19,27H,2,4,8-14H2
SMILES Code
FC1=CC(CCN2CCN(CCCC3=CNC4=C3C=C(N5C=NN=C5)C=C4)CC2)=CC=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
432.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Taniguchi-Takizawa T, Kato H, Shimizu M, Yamazaki H. Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants. Curr Drug Metab. 2021;22(3):208-214. doi: 10.2174/1389200221666201207195758. PMID: 33290197.
2: Schmidt AM, Eilbracht P. Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/Fischer indole synthesis. J Org Chem. 2005 Jul 8;70(14):5528-35. doi: 10.1021/jo050464l. PMID: 15989334.
3: Watt AP, Pike A, Morrison D. Determination of the collisionally activated dissociation of a substituted indole by orthogonal acceleration quadrupole time- of-flight mass spectrometry. J Am Soc Mass Spectrom. 2001 Nov;12(11):1145-52. doi: 10.1016/S1044-0305(01)00299-9. PMID: 11720388.
4: Locker KL, Morrison D, Watt AP. Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001 Jan 5;750(1):13-23. doi: 10.1016/s0378-4347(00)00369-8. PMID: 11204213.
5: Longmore J, Maguire JJ, MacLeod A, Street L, Schofield WN, Hill RG. Comparison of the vasoconstrictor effects of the selective 5-HT1D-receptor agonist L-775,606 with the mixed 5-HT1B/1D-receptor agonist sumatriptan and 5-HT in human isolated coronary artery. Br J Clin Pharmacol. 2000 Feb;49(2):126-31. doi: 10.1046/j.1365-2125.2000.00129.x. PMID: 10671906; PMCID: PMC2014896.
6: Prueksaritanont T, Lu P, Gorham L, Sternfeld F, Vyas KP. Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist. Xenobiotica. 2000 Jan;30(1):47-59. doi: 10.1080/004982500237811. PMID: 10659950.
7: Chambers MS, Street LJ, Goodacre S, Hobbs SC, Hunt P, Jelley RA, Matassa VG, Reeve AJ, Sternfeld F, Beer MS, Stanton JA, Rathbone D, Watt AP, MacLeod AM. 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. J Med Chem. 1999 Feb 25;42(4):691-705. doi: 10.1021/jm980569z. PMID: 10052976.
