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MedKoo Cat#: 146315 | Name: Formicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Formicin is a naturally occurring antibiotic compound produced by Streptomyces species, known for its antimicrobial activity, particularly against Gram-positive bacteria. Its mechanism of action involves inhibition of bacterial protein synthesis by interfering with ribosomal function, though the exact molecular target is less well-characterized than for other antibiotics. Formicin has been explored primarily in research settings for its potential pharmaceutical applications and as a lead compound in antibiotic development.

Chemical Structure

Formicin
Formicin
CAS#625-51-4

Theoretical Analysis

MedKoo Cat#: 146315

Name: Formicin

CAS#: 625-51-4

Chemical Formula: C3H7NO2

Exact Mass: 89.0477

Molecular Weight: 89.09

Elemental Analysis: C, 40.44; H, 7.92; N, 15.72; O, 35.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Formicin;
IUPAC/Chemical Name
N-(hydroxymethyl)acetamide
InChi Key
HWJHZLJIIWOTGZ-UHFFFAOYSA-N
InChi Code
1S/C3H7NO2/c1-3(6)4-2-5/h5H,2H2,1H3,(H,4,6)
SMILES Code
CC(=O)NCO
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 89.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Collins FWJ, O'Connor PM, O'Sullivan O, Rea MC, Hill C, Ross RP. Formicin - a novel broad-spectrum two-component lantibiotic produced by Bacillus paralicheniformis APC 1576. Microbiology (Reading). 2016 Sep;162(9):1662-1671. doi: 10.1099/mic.0.000340. Epub 2016 Jul 22. PMID: 27450592. 2: Khamkar SL, Handore KL, Shinde HM, Reddy DS. Highly Stereoselective Diels- Alder-Based Strategy for the Synthesis of 3-epi-Formicin A and 1-epi-Formicin B. Org Lett. 2024 May 10;26(18):3961-3965. doi: 10.1021/acs.orglett.4c01209. Epub 2024 Apr 28. PMID: 38679880. 3: Du YE, Byun WS, Lee SB, Hwang S, Shin YH, Shin B, Jang YJ, Hong S, Shin J, Lee SK, Oh DC. Formicins, N-Acetylcysteamine-Bearing Indenone Thioesters from a Wood Ant-Associated Bacterium. Org Lett. 2020 Jul 17;22(14):5337-5341. doi: 10.1021/acs.orglett.0c01584. Epub 2020 Jul 6. PMID: 32628492. 4: REMON MIRANDA C. [Poisonings with the commercial preparation, formicin]. Medicina (Madr). 1961 Feb;29:91-8. Spanish. PMID: 13740782. 5: Bossa R, Dubini F, Galatulas I, Taniguchi M. Attività antimitotica della formicina, della chetocaina e della cloroimipramina su leucociti umani in cultura stimolati con fitoemoagglutinina [Antimitotic activity of formicin, ketocaine and chloroimipramine on human leukocytes in culture stimulated with phytohemagglutinin]. Arch Ital Patol Clin Tumori. 1970 Jul-Dec;13(3):135-40. Italian. PMID: 5521382. 6: Kaminsky R, Zweygarth E. Feeder layer-free in vitro assay for screening antitrypanosomal compounds against Trypanosoma brucei brucei and T. b. evansi. Antimicrob Agents Chemother. 1989 Jun;33(6):881-5. doi: 10.1128/AAC.33.6.881. PMID: 2764539; PMCID: PMC284250.