ASM-024 | CAS#1609534-85-1| nicotinic receptor agonist

MedKoo Cat#: 529123 | Name: ASM-024 iodide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASM-024 is a nicotinic receptor agonist potentially for the treatment of asthma and chronic obstructive bronchitis.

Chemical Structure

ASM-024 iodide

CAS#1609534-85-1 (iodide)

Theoretical Analysis

MedKoo Cat#: 529123

Name: ASM-024 iodide

CAS#: 1609534-85-1 (iodide)

Chemical Formula: C15H25IN2

Exact Mass: 0.0000

Molecular Weight: 360.28

Elemental Analysis: C, 50.01; H, 6.99; I, 35.22; N, 7.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1609534-88-4 (cation) 1609534-85-1 (iodide) 1609534-90-8 (tosylate)

Synonym

ASM-024 iodide; ASM-024; ASM024; ASM 024;

IUPAC/Chemical Name

1,1-diethyl-4-phenyl-1,4-diazepan-1-ium iodide

InChi Key

WUFUFYAHIPCTJJ-UHFFFAOYSA-M

InChi Code

InChI=1S/C15H25N2.HI/c1-3-17(4-2)13-8-11-16(12-14-17)15-9-6-5-7-10-15;/h5-7,9-10H,3-4,8,11-14H2,1-2H3;1H/q+1;/p-1

SMILES Code

CC[N+]1(CC)CCN(C2=CC=CC=C2)CCC1.[I-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 360.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM. Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma. Can Respir J. 2015 Jul-Aug;22(4):230-4. PubMed PMID: 26252534; PubMed Central PMCID: PMC4530857. 2: Israël-Assayag E, Beaulieu MJ, Cormier Y. ASM-024, a piperazinium compound, promotes the in vitro relaxation of β2-adrenoreceptor desensitized tracheas. PLoS One. 2015 Mar 23;10(3):e0120095. doi: 10.1371/journal.pone.0120095. PubMed PMID: 25799096; PubMed Central PMCID: PMC4370676. 3: Watson BM, Oliveria JP, Nusca GM, Smith SG, Beaudin S, Dua B, Watson RM, Assayag EI, Cormier YF, Sehmi R, Gauvreau GM. Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand. Int Arch Allergy Immunol. 2014;165(4):255-64. doi: 10.1159/000370068. PubMed PMID: 25660404. 4: Assayag EI, Beaulieu MJ, Cormier Y. Bronchodilatory and anti-inflammatory effects of ASM-024, a nicotinic receptor ligand, developed for the treatment of asthma. PLoS One. 2014 Jan 22;9(1):e86091. doi: 10.1371/journal.pone.0086091. PubMed PMID: 24465890; PubMed Central PMCID: PMC3899211.