TC9-305 | CAS#2092914-16-2 | Apoptosis Inhibitor

MedKoo Cat#: 530523 | Name: TC9-305

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC9-305 is a highly potent apoptosis inhibitor (EC50 = 0.4 nM). The therapeutic potential of these new apoptosis inhibitors was demonstrated by their neuroprotective effect on an ischemic animal model.

Chemical Structure

TC9-305

CAS#2092914-16-2

Theoretical Analysis

MedKoo Cat#: 530523

Name: TC9-305

CAS#: 2092914-16-2

Chemical Formula: C33H37F3N4O6S

Exact Mass: 674.2386

Molecular Weight: 674.74

Elemental Analysis: C, 58.74; H, 5.53; F, 8.45; N, 8.30; O, 14.23; S, 4.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

TC9-305, TC-9-305, TC 9-305, TC9305, TC-9305, TC 9305

IUPAC/Chemical Name

N-(adamantan-1-yl)-4-((4-(1-(3,4-dimethoxybenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-6-(trifluoromethyl)pyrimidin-2-yl)sulfonyl)butanamide

InChi Key

GQVPWRCSKOKXLO-UHFFFAOYSA-N

InChi Code

InChI=1S/C33H37F3N4O6S/c1-45-26-7-5-20(13-27(26)46-2)18-40-19-24(6-8-30(40)42)25-14-28(33(34,35)36)38-31(37-25)47(43,44)9-3-4-29(41)39-32-15-21-10-22(16-32)12-23(11-21)17-32/h5-8,13-14,19,21-23H,3-4,9-12,15-18H2,1-2H3,(H,39,41)

SMILES Code

O=C1C=CC(C2=NC(S(CCCC(NC3(CC4C5)CC5CC(C4)C3)=O)(=O)=O)=NC(C(F)(F)F)=C2)=CN1CC6=CC=C(OC)C(OC)=C6

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 674.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment Li LiXian JiangShaoqiang HuangZhengxin YingZhaolan ZhangChenjie PanSisi LiXiaodong Wangand Zhiyuan Zhang Publication Date (Web): March 1, 2017 (Letter) DOI: 10.1021/acsmedchemlett.6b00489