Synonym
MDT 637; MDT-637; MDT637; VP-14637; VP 14637; VP14637.
IUPAC/Chemical Name
2-((2-hydroxy-5-((E)-((5-methyl-1H-tetrazol-1-yl)imino)methyl)phenyl)(4-hydroxyphenyl)methyl)-4-((Z)-((5-methyl-1H-tetrazol-1-yl)imino)methyl)phenol
InChi Key
BLUJRJMLDHEMRX-VVCLLGATSA-N
InChi Code
InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3/b26-13-,27-14+
SMILES Code
OC1=CC=C(C(C2=CC(/C=N/N3C(C)=NN=N3)=CC=C2O)C4=CC(/C=N\N5N=NN=C5C)=CC=C4O)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
510.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Perron M, Stray K, Kinkade A, Theodore D, Lee G, Eisenberg E, Sangi M, Gilbert BE, Jordan R, Piedra PA, Toms GL, Mackman R, Cihlar T. GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process. Antimicrob Agents Chemother. 2015 Dec 14;60(3):1264-73. doi: 10.1128/AAC.01497-15. PMID: 26666922; PMCID: PMC4776015.
2: Del Vecchio AM, Sarisky RT. Cold virus fusion or stopping fusion cold-- inhibitors of the human respiratory syncytial virus F protein. Recent Pat Antiinfect Drug Discov. 2006 Jun;1(2):247-54. doi: 10.2174/157489106777452647. PMID: 18221150.
3: Douglas JL, Panis ML, Ho E, Lin KY, Krawczyk SH, Grant DM, Cai R, Swaminathan S, Chen X, Cihlar T. Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms. Antimicrob Agents Chemother. 2005 Jun;49(6):2460-6. doi: 10.1128/AAC.49.6.2460-2466.2005. PMID: 15917547; PMCID: PMC1140497.
4: Douglas JL, Panis ML, Ho E, Lin KY, Krawczyk SH, Grant DM, Cai R, Swaminathan S, Cihlar T. Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. J Virol. 2003 May;77(9):5054-64. doi: 10.1128/jvi.77.9.5054-5064.2003. PMID: 12692208; PMCID: PMC153948.
5: De Clercq E. Highlights in the development of new antiviral agents. Mini Rev Med Chem. 2002 Apr;2(2):163-75. doi: 10.2174/1389557024605474. PMID: 12370077.
6: McKimm-Breschkin J. VP-14637 ViroPharma. Curr Opin Investig Drugs. 2000 Dec;1(4):425-7. PMID: 11249694.
