Z118332870 | CAS#1223377-83-0 | dual EGFR/BRD4 inhibitor

MedKoo Cat#: 407404 | Name: Z118332870

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Z118332870 is a potent dual EGFR/BRD4 inhibitor.

Chemical Structure

Z118332870

CAS#1223377-83-0

Theoretical Analysis

MedKoo Cat#: 407404

Name: Z118332870

CAS#: 1223377-83-0

Chemical Formula: C18H18FN3O3

Exact Mass: 343.1332

Molecular Weight: 343.36

Elemental Analysis: C, 62.97; H, 5.28; F, 5.53; N, 12.24; O, 13.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Z118332870; Z-118332870; Z 118332870.

IUPAC/Chemical Name

N-[2-(2-Fluorophenoxy)ethyl]-6,7-dimethoxy-4-quinazolinamine

InChi Key

SQUSZMTZUQQFKO-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H18FN3O3/c1-23-16-9-12-14(10-17(16)24-2)21-11-22-18(12)20-7-8-25-15-6-4-3-5-13(15)19/h3-6,9-11H,7-8H2,1-2H3,(H,20,21,22)

SMILES Code

COC1=CC2=NC=NC(NCCOC3=CC=CC=C3F)=C2C=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 343.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Allen BK, Mehta S, Ember SW, Schonbrunn E, Ayad N, Schürer SC. Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4. Sci Rep. 2015 Nov 24;5:16924. doi: 10.1038/srep16924. PubMed PMID: 26596901; PubMed Central PMCID: PMC4657038.